Myoblast Transfer Therapy

I am pleased to introduce this volume on Myoblast Transfer Therapy on behalf of the Muscular Dystrophy Association and all of its Advisory Committees. The international conference which led to this volume brought together leading basic scientists and clinical investigators for the purpose of coordin...

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Bibliographic Details
Other Authors: Griggs, Robert C. (Editor), Karpati, George (Editor)
Format: eBook
Language:English
Published: New York, NY Springer US 1990, 1990
Edition:1st ed. 1990
Series:Advances in Experimental Medicine and Biology
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Improved Media for Rapid Clonal Growth of Normal Human Skeletal Muscle Satellite Cells
  • Retroviral Lineage Markers for Assessing Myoblast Fate In Vivo
  • Myogenic Conversion of Human Non-muscle Cells for the Diagnosis and Therapy of Neuromuscular Diseases
  • General Discussion
  • 6 Monitoring Clinical Success: Phenotypic Transformation
  • Genetic and Biochemical Determinations in the Pre-transplant Workup and in the Post-transplant Assessment Period
  • Use of Quantitative Myometry in the Evaluation of Myoblast Transfer Therapy
  • Clinical Issues in Myoblast Transfer
  • Quantitation of Muscle Mass and Muscle Protein Synthesis Rate: Documenting a Response to Myoblast Transfer
  • Plausible Structural/Functional/Behavioral/Biochemical Transformations Following Myoblast Transfer Therapy
  • Mdx Mouse as Therapeutic Model System: Development and Implementation of Phenotypic Monitoring
  • Golden Retriever Muscular Dystrophy: Monitoring for Success
  • Molecular Markers for Myoblast Transplantation in GRMD
  • The Role of the Xmd Dog in the Assessment of Myoblast Transfer Therapy
  • The Dilemma of Manifesting Carriers in the Context of Myoblast Transplantation
  • Immunosuppressive Therapy in Duchenne Muscular Dystrophy: Considerations for Myoblast Transfer Studies
  • General Discussion
  • 7 Implementation of Human Trials
  • Synopsis of Proceedings of the Workshop on the Implementation of Myoblast Transfer in Humans
  • Participants
  • 1 Molecular Biology of Myogenesis and Regeneration
  • MyoD: A Regulatory Gene of Skeletal Myogenesis
  • Myoblasts, Satellite Cells, and Myoblast Transfer
  • Regeneration of Skeletal Muscle Fibers after Necrosis
  • Detection of Truncated Dystrophin in Fetal DMD Myotubes
  • General Discussion
  • 2 Myoblast/Satellite Cell Antigenicity
  • Immunological Aspects of Histoincompatible Myoblast Transfer into Non-tolerant Hosts
  • A Comparison of Long-term Survival of Muscle Precursor Cell Suspensions and Minced Muscle Allografts in the Non-tolerant Mouse
  • N-CAM is a Target Cell Surface Antigen for the Purification of Muscle Cells for Myoblast Transfer Therapy
  • Immunochemical Analyses of the Myoblast Membrane and Lineage
  • General Discussion
  • 3 Practical Aspects of Myoblast Implantation
  • The Principles and Practice of Myoblast Transfer
  • Myoblast Transfer Improves Muscle Genetics/Structure/ Function and Normalizes the Behavior and Life Span of Dystrophic Mice
  • Practical Aspects of Myoblast Implantation: Investigations on Two Inherited Myopathies in Animals
  • Purification and Proliferation of Human Myoblasts Isolated with Fluorescence Activated Cell Sorting
  • The Proliferation and Fusion of Myoblasts In Vivo
  • The DMD Gene Promoter: A Potential Role in Gene Therapy
  • General Discussion
  • 4 In Situ Fusion: Nuclear Domains and mRNA/Protein Migration
  • Fibroblasts Fuse with Myotubes Developing in Culture
  • Phenotypic and Functional Reversion of Muscular Dysgenesis by Heterotypic Fibroblast-Myotube Fusion In Vitro
  • Control of Satellite Cell Proliferation
  • Regeneration of Skeletal Muscle Induced by Satellite Cell Grafts
  • Localization of Muscle Gene Products in Nuclear Domains: Does this Constitute a Problem for Myoblast Therapy?
  • Mouse Chimeras and Genetic Rescue of Mosaic Muscle
  • General Discussion
  • 5 Development of Myogenic Cell Cultures