Protein Design and the Development of New Therapeutics and Vaccines
| Other Authors: | , |
|---|---|
| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer US
1990, 1990
|
| Edition: | 1st ed. 1990 |
| Series: | New Horizons in Therapeutics
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- I. Advances in the Structural Analysis of Proteins
- 1 Dynamic Processes in Proteins by X-Ray Diffraction
- 2 Mass Spectrometric Methods for Determination of the Structure of Peptides and Proteins
- II. Protein Folding and Stability
- 3 Protein Folding and Stability
- 4 Genetic Analysis of Polypeptide Chain Folding and Misfolding in Vivo
- 5 Unfolding and Inactivation: Genetic and Chemical Approaches to the Stabilization of T4 Lysozyme and Human Interferon Gamma against Irreversible Thermal Denaturation
- III. Principles of Receptor Design and Regulation
- 6 Protein—Tyrosine Kinases and Their Substrates: Old Friends and New Faces
- IV. The Guanine Nucleotide Binding Protein Family
- 7 G Proteins: A Family of Signal-Transducing Molecules
- 8 Model of Signal Transduction by G Proteins: Roles of a Subunits and ?? Dimers in Regulation of Ionic Channels and Adenylyl Cyclase
- 9 Structural Homologies in G-Binding Proteins
- V. Modeling and Structure Prediction in Macromolecules
- 10 Knowledge-Based Protein Modeling and the Design of Novel Molecules
- 11 Computer Simulation Methods as Applied to Site-Specific Mutations
- 12 Dihydrofolate Reductase: A Paradigm for Drug Design
- VI. Protein Engineering and Enzyme Design
- 13 Chemical Approaches to Protein Engineering
- 14 New Engineered Proteins for Use in Therapy and Vaccine Design
- 15 Receptor-Based Design of Dihydrofolate Reductase Inhibitors
- VII. Macromolecules and Targeted Drug Delivery
- 16 Control of the Biological Dispersion of Therapeutic Proteins
- 17 Antibody-Mediated Drug Delivery
- 18 Semisynthetic Catalytic Antibodies
- VIII. Strategies for Directed Mutagenesis of Proteins
- 19 Engineering Novel, Prolonged-Acting Insulins
- IX. Design of Novel Antiviral Agents and Vaccines
- 20 Studies on the Structure andFunction of Ubiquitin
- 21 Recognition at Membrane Surfaces: Influenza HA and Human HLA.