Induced Mutagenesis Molecular Mechanisms and Their Implications for Environmental Protection
Concern is often expressed that our environment may include an increasingly large variety of mutagens, but the extent of the potential hazard they pose has yet to be fully evaluated. A variety of empirical procedures has been devised with which to estimate the mutagenic potency of suspect agents, an...
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| Format: | eBook |
| Language: | English |
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New York, NY
Springer US
1983, 1983
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| Edition: | 1st ed. 1983 |
| Series: | Basic Life Sciences
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- Session I: Mutagen/DNA Interactions
- Mutagenic effects of nucleic acid modification and repair assessed by in vitro transcription
- Genetic effects of bisulfite: Implications for environmental protection
- Session II: Infidelity and Specificity
- Infidelity of DNA replication as a basis of mutagenesis
- The specificity of infidelity of DNA polymerase
- Replication and mutagenesis of irradiated single-strand phage DNA
- Mutational specificity of UV light: Influence of excision repair and the mutator plasmid pKM101
- Session III: Genetic Analysis of Mutagenesis
- Regulation and function of cellular gene products involved in UV and chemical mutagenesis in E. coli
- Differential sensitivity to certain DNA-damaging treatments, including 8-methoxypsoralen plus 340nm ultraviolet irradiation, between K-12 and B/r strains of Escherichia coli
- The use of DNA-repair deficient mutants of Chinese Hamster ovary cells in studying mutagenesis mechanisms and in testing for environmental mutagens
- Session IV: Mammalian Systems
- Variation in response to mutagens amongst normal and repair-defective human cells
- Relationship between excision repair and the cytotoxic and mutagenic action of chemicals and UV radiation
- The induction of resistance to alkylation damage in mammalian cells
- Induced mutagenesis of simian virus 40 infecting carcinogen-treated monkey cells
- Session V: Human Systems and Environmental Protection
- Analysis of chemically induced mutation in single cell populations
- Adaptability of microbial mutagenicity assays to the study of problems of environmental concern
- Final Discussion
- Participants