Randomised Controlled Clinical Trials
After 13 years there are new areas to discuss and more recent trials to be included. Good clinical practice; evaluation of quality of life; measurement of the benefit:risk comparison; determination of cost- effectiveness and cost utility; stopping rules for trials; meta-analysis and subgroup analysi...
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| Format: | eBook |
| Language: | English |
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New York, NY
Springer US
1996, 1996
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| Edition: | 2nd ed. 1996 |
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| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 1. Introduction
- 2. The history of controlled trials
- 3. Ethical considerations
- 4. The objectives of a randomised controlled trial
- 5. Different trial designs
- 6. How many subjects are required for a trial?
- 7. How to ensure that the results are free of bias
- 8. Writing the protocol
- 9. Recruitment of subjects
- 10. Information to be collected during a trial
- 11. The conduct of the trial — Good Clinical Practice
- 12. Stopping rules for trials
- 13. The variability and validity of results
- 14. Analysis of the results, subgroup and meta-analysis
- 15. The evaluation of subjective well-being and measurement of quality of life
- 16. The detection of adverse drug reactions
- 17. Measurement of the benefit; risk comparison, cost-effectiveness and cost-utility
- 18. Early trials on new drugs
- 19. Failure to accept the results of randomised controlled trials
- 20. The advantages and disadvantages of randomised controlled trials
- References