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Heat Shock Proteins and Cytoprotection Atp-Deprived Mammalian Cells

Bibliographic Details
Main Authors: Kabakov, Alexander E., Gabai, Vladimir L. (Author)
Format: eBook
Language:English
Published: New York, NY Springer US 1997, 1997
Edition:1st ed. 1997
Series:Molecular Biology Intelligence Unit
Subjects:
Humanities And Social Sciences
Humanities
Social Sciences
Biochemistry
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 4.2. Ischemia-Induced HSP Synthesis in the Heart
  • 4.3. Stress Protein Expression in Post-Ischemic Brain
  • 4.4. Ischemia-Induced Stress Protein Synthesis in Other Normal Tissues and Tumor Cells
  • 4.5. Possible Mechanisms of HSP Accumulation After ATP Depletion
  • Concluding Remarks
  • 5. Heat Shock Proteins and Cardioresistance to Ischemia
  • 5.1. Heat Shock-Induced Cardioresistance to Ischemia/Reperfusion Injury
  • 5.2. The Role of Myocardial HSPs in Ischemie Preconditioning
  • 5.3. The Cardioresistance Induced by Other Stimuli Can Also Be Associated with HSPs
  • 5.4. Evidence for the Involvement of HSP70 in Cardioprotection
  • 5.5. Are Other Stress Proteins Cardioprotective?
  • Concluding Remarks
  • 6. Involvement of Heat Shock Proteins in Protection of Various Normal and Tumor Cells from Ischemic Insult
  • 6.1. HSPsand Ischemic Tolerance in the Brain
  • 6.2. Ischemic Tolerance in the Kidney
  • 6.3. HSPs and Protection from Ischemia of Other Organs and Tissues
  • 6.4.
  • Concluding Remarks
  • 7. What Are the Mechanisms of Heat Shock Protein-Mediated Cytoprotection Under ATP Deprivation?
  • 7.1. Two Paradigms of Cell Tolerance to ATP Deprivation: Reduced Injury During the Stress and the Improved Post-Stress Recovery
  • 7.2. Chaperoning Under ATP Depletion as a Special Function of HSP70
  • 7.3. How Other Stress Proteins Might Maintain the Viability of ATP-Deprived Cells
  • 7.4. How Do HSPs Protect Cells against Necrosis during ATP Depletion?
  • 8. Mechanisms of Heat Shock Protein-Mediated Protection from Ischemia-Induced Apoptosis
  • 8.1. HSPs and Triggering of Apoptosis in Ischemic Cells
  • 8.2. HSPs and Transduction of the Apoptotic Signal
  • 8.3. HSPs and the Execution of Apoptosis
  • 9. Conclusions and Perspectives
  • 9.1. Adaptation to Energy Starvation on The Molecular Level
  • 9.2. Heat Shock Proteins and Ischemia: Significance for Medicine
  • Concluding Remarks
  • 1. Heat Shock Proteins and the Regulation of Heat Shock Gene Expression in Eukaryotes
  • 1.1. The Family of Stress Proteins and Molecular Chaperones
  • 1.2. The Regulation of Heat Shock Gene Expression in Eukaryotes
  • Concluding Remarks
  • 2. ATP Homeostasis, Ionic Balance and Cell Viability
  • 2.1. ATP Homeostasis in Mammalian Cells
  • 2.2. Cell Viability and ATP Depletion
  • 2.3. Significance of Ionic Imbalance for the Death of ATP-Depleted Cells
  • 2.4. Mitochondrial Dysfunction and Damage During Ischemia
  • Concluding Remarks
  • 3. “Proteotoxicity” of ATP Depletion: Disruption of the Cytoskeleton, Protein Aggregation and Involvement of Molecular Chaperones
  • 3.1. The Cytoskeleton Under ATP Deprivation
  • 3.2. Protein Aggregation in Energy-Deprived Cells
  • 3.3. How Do Heat Shock Proteins Respond to ATP Depletion?
  • Concluding Remarks
  • 4. ATP Depletion as Inducer of Heat Shock Protein Expression
  • 4.1. Anoxia and Mitochondrial Inhibitors Activate HSP Gene Expression

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