Leukocyte Recruitment, Endothelial Cell Adhesion Molecules, and Transcriptional Control Insights for Drug Discovery
The localized attachment of circulating leukocytes to endothelium has been recognized as the cellular hallmark of the inflammatory response. This adhesive interaction, a necessary antecedent to the emigration of leukocytes from the blood into the tissues, is mediated by vascular adhesion molecules....
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| Format: | eBook |
| Language: | English |
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New York, NY
Springer US
2001, 2001
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| Edition: | 1st ed. 2001 |
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| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 1. The Selectins in Leukocyte Recruitment
- 2. Transcriptional Regulation of the E-Selectin Gene
- 3. The Immunoglobulin Superfamily in Leukocyte Recruitment
- 4. Regulation of Intercellular Adhesion Molecule (ICAM) Gene Expression
- 5. Transcriptional Regulation of VCAM-1
- 6. Activation of Nuclear Factor-KB
- 7. The Basal Transcriptional Apparatus
- 8. Therapeutic Regulation of Leukocyte Adhesion Molecule Expression
- 9. The NF-kB System and Drug Discovery