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140122 ||| eng |
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|a 9781461512431
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| 100 |
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|a Gupta, Sudhir
|e [editor]
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| 245 |
0 |
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|a Mechanisms of Lymphocyte Activation and Immune Regulation VIII
|h Elektronische Ressource
|b Autoimmunity 2000 and Beyond
|c edited by Sudhir Gupta
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| 250 |
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|a 1st ed. 2001
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| 260 |
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|a New York, NY
|b Springer US
|c 2001, 2001
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| 300 |
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|a VIII, 136 p
|b online resource
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| 505 |
0 |
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|a Basic Mechanisms -- Delineation of the Pathogenesis of Systemic Lupus Erythematosus by Using Murine Models -- Factors Contributing to Autoimmune Disease -- Control of Autoimmunity by Regulatory T Cells -- Autoimmunity, Self-Tolerance, and Immune Homeostasis: From Whole Animal Phenotypes to Molecular Pathways -- Peripheral Tolerance and Organ Specific Autoimmunity -- Autoimmune Lymphoproliferative Syndrome: Types I, II, and Beyond -- Pathogenesis -- The Role of MHC Class II Molecules in the Pathogenesis and Prevention of Type I Diabetes -- Control of Autoreactive T Cell Activation by Immunoregulatory T Cells -- Immune Tolerance and The Nervous System -- Functional Role of Epitope Spreading in the Chronic Pathogenesis of Autoimmune and Virus-Induced Demyelinating Diseases -- Therapy -- Multiple Sclerosis and Gene Expression Profiling -- Treatment of Autoimmunity by Inhibition of T Cell Costimulation -- Cytokine Blockade in Rheumatoid Arthritis
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| 653 |
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|a Microbiology
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| 653 |
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|a Immunology
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| 653 |
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|a Biochemistry
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| 653 |
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|a Pathology
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| 041 |
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|a eng
|2 ISO 639-2
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| 989 |
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|b SBA
|a Springer Book Archives -2004
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| 490 |
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|a Advances in Experimental Medicine and Biology
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| 028 |
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|a 10.1007/978-1-4615-1243-1
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| 856 |
4 |
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|u https://doi.org/10.1007/978-1-4615-1243-1?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
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|a 572
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| 520 |
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|a Advances in biochemistry, cell biology, genome-wide mutagenesis - coupled with molecular technology, including gene microarray and transgenic and knock-out animals - have been instrumental in understanding the cellular processes and molecular pathways of self-tolerance and autoimmune diseases. The molecular definition of these pathways and processes has led to novel treatments for certain auto-immune diseases that are based on the pathogenesis of diseases rather than on broad-spectrum immunosuppression. This book reviews many of these current developments and proposes future novel approaches for understanding the pathogenesis of auto-immune diseases and designing novel therapy. This book covers three major areas of auto-immunity: the basic mechanisms of immunological tolerance, pathogenesis of auto-immune diseases, and some novel therapies. This book should be useful for immunologists, molecular biologists, rheumatologists, and clinical scientists
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