Cyclic ADP-Ribose and NAADP Structures, Metabolism and Functions

In the past decade we have witnessed the birth and maturing of a field of research centering on the Ca2+ signaling functions of cyclic ADP-ribose (cADPR) and nicotinic acid adenine dinucleotide phosphate (NAADP), which structures and mechanisms of action are truly unique among all Ca2+ messengers. A...

Full description

Bibliographic Details
Main Author: Hon Cheung Lee
Format: eBook
Language:English
Published: New York, NY Springer US 2002, 2002
Edition:1st ed. 2002
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Cyclic ADP-Ribose and NAADP A Story of Two Calcium Messengers
  • ADP-Ribosyl Cyclases — A Family of cADPR and NAADP Metabolizing Enzymes
  • Regulation of Synthesis of cADPR and NAADP
  • A Natural History of the Human CD38 Gene
  • A Yeast Expression System of High Efficiency for Producing Recombinant Enzymes
  • Novel Cycling Assays for cADPR and NAADP
  • Pharmacology of Cyclic ADP-Ribose and NAADP Synthesis and Properties of Analogs
  • Separate but Interacting Calcium Stores
  • Sensitizing Calcium-Induced Calcium Release Role of cADPR as an Endogenous Modulator
  • Spatial and Temporal Control of Calcium Signaling by NAADP
  • Regulation of Immune Responses by CD38 and cADPR
  • Subcellular and Extracellular Trafficking of NAD+ and Cyclic ADP-Ribose: A New Way for Regulating Intracellular Calcium Homeostasis
  • The CD38-Cyclic ADP-Ribose Signal System in Pancreatic ß- Cells
  • The Role of cADPR and NAADP in T Cell Calcium Signaling and Activation
  • Calcium Signaling by cADPR in Cardiac Myocytes
  • Cyclic ADP-Ribose and Vasomotor Response
  • Coordination of Calcium Signaling by cADPR and NAADP in Pancreatic Acinar Cells
  • Calcium and Calcium-Linked Second Messengers are Main Actors in the Maturation and Fertilization of Starfish Oocytes
  • ADP-Ribosylation and CD38 Signaling
  • Retinoid-Mediated Signaling and CD38 Expression
  • Calcium Regulation in Smooth Muscle Through the CD38/Cyclic ADP-Ribose Pathway
  • Author Index