Cell Mechanics and Cellular Engineering

Cell mechanics and cellular engineering may be defined as the application of principles and methods of engineering and life sciences toward fundamental understanding of structure-function relationships in normal and pathological cells and the development of biological substitutes to restore cellular...

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Bibliographic Details
Other Authors: Mow, Van C. (Editor), Guilak, Farshid (Editor), Tran-Son-Tay, Roger (Editor), Hochmuth, Robert M. (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 1994, 1994
Edition:1st ed. 1994
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • I Constitutive Modeling and Mechanical Properties of Circulating Cells
  • 1. Human Neutrophils under Mechanical Stress
  • 2. Viscous Behavior of Leukocytes
  • 3. Shear Rate-Dependence of Leukocyte Cytoplasmic Viscosity
  • 4. Cell Tumbling in Laminar Flow: Cell Velocity is a Unique Function of the Shear Rate
  • II Flow-Induced Effects on Cell Morphology and Function
  • 5. The Regulation of Vascular Endothelial Biology by Flow
  • 6. Flow Modulation of Receptor Function in Leukocyte Adhesion to Endothelial Cells
  • 7. Osteoblast Responses to Steady Shear Stress
  • 8. Effects of Shear Stress on Cytoskeletal Structure and Physiological Functions of Cultured Endothelial Cells
  • III Mechanics and Biology of Cell-Substrate Interactions
  • 9. Kinetics and Mechanics of Cell Adhesion under Hydrodynamic Flow: Two Cell Systems
  • 10. Initial Steps of Cell-Substrate Adhesion
  • 11. A Cell-Cell Adhesion Model for the Analysis of Micropipette Experiments
  • IV Cell-Matrix Interactions and Adhesion Molecules
  • 12. Biphasic Theory and In Vitro Assays of Cell-Fibril Mechanical Interactions in Tissue-Equivalent Gels
  • 13. Mechanical Load ± Growth Factors Induce [Ca2+]i Release, Cyclin D1 Expression and DNA Synthesis in Avian Tendon Cells
  • 14. Cytomechanics of Transdifferentiation
  • V Molecular and Biophysical Mechanisms of Mechanical Signal Transduction
  • 15. Signal Transduction Cascades Involved in Mechanoresponsive Changes in Gene Expression
  • 16. Cytoskeletal Plaque Proteins as Regulators of Cell Motility, and Tumor Suppressors
  • 17. Mechanical Signal Transduction and G Proteins
  • 18. Modeling Mechanical-Electrical Transduction in the Heart
  • 19. Cellular Tensegrity and Mechanochemical Transduction
  • VI Physical Regulation of Tissue Metabolic Activity
  • 20. Stress, Strain, Pressure and Flow Fields in Articular Cartilage and Chondrocytes
  • 21. Deformation-Induced Calcium Signaling in Articular Chondrocytes
  • 22. The Effects of Hydrostatic and Osmotic Pressures on Chondrocyte Metabolism
  • 23. Proteoglycan Synthesis and Cytoskeleton in Hydrostatically Loaded Chondrocytes
  • 24. Altered Chondrocyte Gene Expression in Articular Cartilage Matrix Components and Susceptibility to Cartilage Destruction
  • VII Mechanics of Cell Motility and Morphogenesis
  • 25. Mechanics of Cell Locomotion
  • 26. The Correlation Ratchet: A Novel Mechanism for Generating Directed Motion by ATP Hydrolysis
  • 27. Receptor-Mediated Adhesive Interactions at the Cytoskeleton/Substratum Interface during Cell Migration
  • 28. Actin Polymerization and Gel Osmotic Swelling in Tumor Cell Pseudopod Formation
  • 29. Biomechanical Model for Skeletal Muscle Microcirculation with Reference to Red and White Blood Cell Perfusion and Autoregulation