Protein Conformation as an Immunological Signal

This volume is the collection of papers presented during a four day meeting, the EMBO workshop "Protein Conformation as an Immunological Signal" that took place at Portovenere (La Spezia), Italy, October 1-4, 1981. The motivation that drove us to organize this meeting was the feeling that...

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Bibliographic Details
Main Authors: Celada, Franco, Schumaker, Verne N. (Author), Sercarz, Eli E. (Author)
Format: eBook
Language:English
Published: New York, NY Springer US 1983, 1983
Edition:1st ed. 1983
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Antigen Structures Used by Regulatory T Cells in the Interaction Among T Suppressor, T Helper and B Cells
  • Activation of Human B Lymphocytes by Antigen Specific T Cell Lines
  • T Helper Cell Recognition of Two Types of Mouse Lambda Light Chains
  • Effects of Anti-Idiotypic Sera (Ab-2) and Monoclonal Idiotypic Antibody (Ab-1) on the Immune Response to a Simple Polypeptide Antigen with only two Immunologically Active Epitopes. Analysis of the Response at the Unideterminant Level
  • Topic IX. Effector Mechanisms for Cell Signaling Resulting from Antigen-Antibody Interactions
  • The Role of IgE and its Receptor in Mediating Secretion
  • A New Method for Monitoring Intracellular Free Ca2+ in Lymphocytes. Concanavalin A and Anti-Igm Induce an Early Rise of Cytoplasmic Free Ca2+
  • B Lymphocyte Stimulation and Suppression by the Fc Portion of Immunoglobulin
  • Modulation of Immunological Reactivity by the Fc Piece of Immunoglobulin
  • Topic I. The Influence of Antigen Upon the Conformation of Antibody
  • Antibody-Hapten Binding Kinetics, Conformational Transitions and Domains Interactions
  • Dynamic Aspects of Signal Transfer in Antibody Molecules
  • Could Aggregation of Human Immunoglobulins Bring About Appearance of Novel Antigenic Sites?
  • Topic II. Structure/Function Interrelationships in IgM and IgG
  • Immunoglobulin M Conformational Change is a Signal for Complement Activation
  • Expression of Fc Effector Function in Homogeneous Murine Anti-ARS IgM
  • The Localization of Effector Sites on Immunoglobulin G
  • Human Fc? Fragment: Location of Acidic Residues Involved in Complement Activation
  • Topic III. Structure Of C1, Interactions Between its Subunits and Other Macromolecules
  • Ultrastructure of the First Component of Human Complement
  • Binding of Human 125I-Fibronectin to C1q and to Human Monoclonal Myeloma IgG Subclasses
  • Biochemical Specificity of Human Complement Component C1q
  • Antibody-mediated Activation of Genetically Defective Escherichia coli Galactosidases by Monoclonal Antibodies
  • Synergistic Activation by Monoclonal Antibodies of ?-galactosidase from Genetically Defective E. coli
  • Antibodies as Probes of Protein Structure
  • Is There a Preferential Pathway for Antibody-mediated Enzyme Activation?
  • Topic VII. The Recognition by T Cells of Protein Antigens
  • General Introduction
  • VIIa. Which are the Antigenic Determinants that T Cells Recognize?
  • T Lymphocyte Recognition of Small Peptide Antigens: Formation of Neoantigenic Determinants and Clonal Frequency Resulting in Ir Gene Control
  • The Antigenic Structure of Bovine Serum Albumin: T-Cell, B-Cell, and Ia Determinants
  • Attempts to Understand the Function of Macrophages and Antigen Specific Cells in their Mutual Interaction
  • A Possible Immunodominant Domain on Myoglobin Recognized by T Lymphocytes
  • VIIb. What is the Role of MHC and Other Genes in the Antigen-presenting cell?
  • Antigen Presenting Function of Macrophages
  • The Sorting-Out Problem in Antigen Presentation
  • Genetic Analysis of Responsiveness to Adjuvant-Free Immunological Signals: Transfer of Genes from Responder Strains (SJL/J and CE/J) to a Nonresponder Background Uncovers a Requirement for H-2 Heterozygosity
  • How is Adjuvanticity Recognised?
  • VIIc. Analysis of the Ternary Complex of Antigen: MHC: and T-cell Receptor with T cell Clones
  • Specificity and Restriction of T Cells in a System of Complementing Ir Genes
  • Evidence for Ia-Antigen Interaction in T Cell Activation
  • Somatic T Cell Hybrids in the Analysis of H-2 Restriction and Antigen Recognition
  • Topic VIII. Structural Aspects of T-B and T-TInteraction
  • Antigen Bridging in T Cell-B Cell Interaction: Fact or Fiction?
  • B Cells as MHC Restricted Antigen Presenting Cells: A Model for T-B Interaction
  • A View from the Bridge: Antigenic Determinants in Immunoregulation
  • Sequence Studies on Human Complement Subcomponent C1r
  • Topic IV. The Activation of the First Component of Complement
  • Dissociation of C1 and Concentration Dependence of Its Activation Kinetics
  • Fluid Phase Activation of Proenzymic C1r
  • Activation of Mammalian Complement by Chicken C1q
  • Topic V. The Importance of Antigen Conformation for Antigenicity and Immunogenicity
  • Conformational Antigenic Determinants in Proteins
  • Topographic Antigenic Determinants Detected by Monoclonal Antibodies to Myoglobin
  • Role of Conformation on the Antigenic Determinants of Tobacco Mosaic Virus Protein
  • Monoclonal Antibodies May Block Sterically or Conformationally the Antigenic Determinants of Human Growth Hormone
  • An Immunochemical Study of the Changes in Conformation Undergone by Two Domains of the Tryptophan-synthetase ?2Subunit upon Association
  • Topic VI. The Changes in Protein Antigen Conformation Induced by Antibody
  • T Cell Replacing Factor (TRF)-Induced IgG Production in a Human B Cell Line and the Mechanism of Transmembrane Signaling through TRF-Acceptors