Molecular Biology of Mutagens and Carcinogens
This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of resea...
| Main Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer US
1983, 1983
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| Edition: | 1st ed. 1983 |
| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- I Introduction
- II Chemicals as Environmental Mutagens and Carcinogens
- III Intrinsic Properties of Nucleic Acids
- A. Introduction 15
- B. Reactions with Water
- C. Reversible Equilibrium Reactions
- D. Fidelity in Nucleic Acid Synthesis
- E. Transcription and Replication of Modified Templates
- IV Reactions of Directly Acting Agents with Nucleic Acids
- A. Introduction
- B. Simple Nonalkylating Agents
- C. Monofunctional Alkylating Agents
- D. Bifunctional Alkylating Agents
- E. Cyclic Alkylating Agents
- F. Vinyl Halides
- G. Alkyl Carbamates
- V Metabolic Activation of Carcinogens and Mutagens
- A. Enzymatic Activation of Polycyclic Aromatic Hydrocarbons
- B. Specific Metabolites of Polycyclic Aromatic Hydrocarbons
- C. Enzymatic Activation of N-Substituted Aromatic Compounds and Resulting Metabolites
- D. Summary
- VI Reactions of Metabolically Activated Carcinogens with Nucleic Aclds
- A. Detection of DNA-Carcinogen Adducts
- B. Polycyclic Aromatic Hydrocarbons
- C. N-Substituted Aromatic Compounds
- D. Naturally Occurring Carcinogens
- VII Conformation of DNA Modified by Bulky Aromatic Carcinogens
- A. Introduction
- B. Methods of Analysis
- C. Conformation of DNA-7,8-Dihydrodiol-9,lO-Oxide-Benzo[a]pyrene Adducts
- D. Conformation of DNA Modified by N-Substituted Aromatic Compounds
- VIII Repair in Mammalian Organs and Cells
- A. Introduction
- B. In Vivo Removal of Alkyl Derivatives
- C. Mechanisms of Repair of Alkyl Derivatives in Eukaryotes
- D. In Vivo Removal of Aromatic Derivatives
- IX Site-Directed Mutagenesis
- Appendix A UV Spectral Characteristics and Acidic Dissociation Constants of Modified Bases, Nucleosides, and Nucleotides
- Appendix B Acid, Neutral, and Basic Spectra of Bases, Nucleosides, Nucleotides, and 55 Modified Derivatives