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Biophysics and Cancer

Since the early times of the Greek philosophers Leucippus and Democritus, and later of the Roman philosopher Lucretius, a simple, fundamental idea emerged that brought the life sciences into the realm of the physical sciences. Atoms, after various interactions, were assumed to acquire stable configu...

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Bibliographic Details
Main Author: Nicolini, Claudio
Format: eBook
Language:English
Published: New York, NY Springer US 1986, 1986
Edition:1st ed. 1986
Subjects:
Physiology
Animal Physiology
Biophysics
Oncology
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 1. Normal Cells and Cancer Cells: Macromolecular Structures and Cellular Functions
  • 1.1. Background
  • 1.2. Native Chromatin-DNA Structure
  • 1.3. Nuclear Structure
  • 1.4. What Is a Gene?
  • 1.5. Ribosomes
  • 1.6. Modification in the Control of Cell Proliferation
  • 1.7. Modifications in the Control of Cell Differentiation
  • 1.8. Modifications in the Control of Cell Transformation
  • 1.9. Modifications in the Control of Cellular Aging
  • 1.10. Membranes
  • 1.11. Cytoskeleton
  • 1.12. Control Mechanisms for Normal versus Abnormal Cell Growth
  • 1.13. Molecular Mechanisms and Models for Gene Expression
  • 1.14. Conclusions and Future Trends
  • 2. Cancer Cause and Prevention
  • 2.1. Background
  • 2.2. Possible Causes of Cancer
  • 2.3. Cancer Prevention
  • 3. Cancer Detection and Treatment
  • 3.1. Background
  • 3.2. Present Status of Human Cancer Detection and Treatment
  • 3.3. Alternative Analytical Approaches
  • 3.4. New Observables
  • 3.5. Theoretical Simulation at the Cellular Level: Optimized Drug Metabolism Parameters in Animals
  • 3.6. Treatment Optimization in Animals
  • 3.7. Drug Interaction and Molecular Perturbation in Animals
  • 3.8. Extrapolation to Human Cancer
  • 4. Experimental Probes
  • 4.1. Background
  • 4.2. Preparative Tools
  • 4.3. Probes for Lower-Order Structures
  • 4.4. Probes for Higher-Order Structures in Situ
  • 5. Theoretical Probes
  • 5.1. Background
  • 5.2. Enzyme Kinetics
  • 5.3. Signal Processing and Analysis
  • 5.4. Statistical Mechanics and Thermodynamics of Cell Structures
  • 5.5. Polyelectrolyte Theory of Interactions among Biopolymers
  • 5.6. Physicochemical Model for Dye-Nucleic Acid Interaction in Situ
  • 5.7. Electromagnetic Theory of Polarized Light Scattering by Large Biopolymers
  • 5.8. Random Walk Model of Biopolymers
  • 5.9. Mean Field Theory of Gel Biopolymers
  • Epilogue: A Final Comment
  • Problems
  • References

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