Renal Stone Disease Pathogenesis, Prevention, and Treatment

CHARLES Y. c. PAK Major progress has been made in the pathophysiologic elucidation and management of nephrolithiasis during the past two decades. It is now possible to detect the cause of stone disease in more than 95% of patients, to prevent recurrent formation of stones in the majority of patients...

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Bibliographic Details
Other Authors: Pak, Charles Y.C. (Editor)
Format: eBook
Language:English
Published: New York, NY Springer US 1987, 1987
Edition:1st ed. 1987
Series:Topics in Renal Medicine
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
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505 0 |a 1. Physiochemistry of urinary stone formation -- 2. Pathogenesis of Hypercalciuria -- 3. Pathophysiology of nonhypercalciuric causes of stones -- 4. Nutritional aspects of stone disease -- 5. Radiologic considerations -- 6. Diagnostic considerations -- 7. Prevention of recurrent nephrolithiasis -- 8. Potassium citrate therapy of nephrolithiasis -- 9. Struvite stones -- 10. Contemporary approaches to removal of renal and ureteral calculi 
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520 |a CHARLES Y. c. PAK Major progress has been made in the pathophysiologic elucidation and management of nephrolithiasis during the past two decades. It is now possible to detect the cause of stone disease in more than 95% of patients, to prevent recurrent formation of stones in the majority of patients, and to remove most existing stones less invasively. The assumption of editorship of this book permits me to indulge in the discussion of this progress from my personal perspective. Three somewhat fortuitous events in my academic career dictated my directing major efforts in stone research. The first event occurred in 1963 when, after having completed medical training, I was faced with two years of military service as a participant of the Berry plan. Choices were limited and disconcerting for someone interested in a research career: a staff physician at a military installation or an indian reservation, or a member of a research team in a state penitentiary. An interesting article by Norman Gershfeld on phospholi­ pid monolayers prompted me to write him seeking a position in his laboratory of Health (NIH) in Bethesda, MD. Partly because of at the National Institutes my rudimentary exposure and publication in surface chemistry, I was offered a position as a staff scientist and a position in the Public Health Service which satisfied the requirements of a military service