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Handbook of Psychopharmacology Volume 20 Psychopharmacology of the Aging Nervous System

"Psychopharmacology of the Aging Nervous System" was selected as the topic for Volume 20 of the Handbook of PsychopharmacoloffY. Senile dementia is now widely recognized as a medical and social problem likely to reach epidemic proportions by the turn of the century. By that time it is esti...

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Bibliographic Details
Other Authors: Iversen, Leslie L. (Editor), Iversen, Susan D. (Editor), Snyder, Solomon H. (Editor)
Format: eBook
Language:English
Published: New York, NY Springer US 1988, 1988
Edition:1st ed. 1988
Subjects:
Neuroscience
Neurosciences
Pharmacology
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • 8. References
  • 4 Chemical Neuroanatomy of Alzheimer’s Disease
  • 1. Introduction: Relationship of Neural Connections and Neurotransmitters with Alzheimer Pathology
  • 2. Limbic and Cortical Connections and Neurotransmitters in Alzheimer’s Disease
  • 3. Brain Stem and Basal Forebrain-Cortical Connections and Neurotransmitters in Alzheimer’s Disease
  • 4. Implications for the Pathogenesis and Treatment of Alzheimer’s Disease
  • 5. References
  • 5 Dementia in Parkinson’s Disease
  • 1. Introduction
  • 2. Brain Lesions in Patients with Parkinson’s Disease
  • 3. Dementia and Lesions
  • 4. Parkinsonian Dementia
  • 5. Symptoms and Lesions
  • 6. Conclusion
  • 7. References
  • 6 Alzheimer’s Disease: Genetic Theories of Etiology
  • 1. Introduction
  • 2. The Genetic Hypothesis
  • 3. Critical Methodological Issues
  • 4. PredictedCharacteristics of Genetically Caused AD
  • 5. Review of Previous Studies
  • 6. Current Studies
  • 7. Implications and Strategies for Future Research
  • 1 Neuropathological and Neurochemical Aspects of Alzheimer’s Disease
  • 1. Introduction
  • 2. The Neuropathology of Alzheimer’s Disease
  • 3. Alzheimer-Type Changes in Conditions Other than Alzheimer’s Disease
  • 4. Alzheimer’s Disease and Patient Age
  • 5. Biochemical Correlates of Pathological Changes
  • 6. Relationship between Plaques and Tangles and Nerve Cell Atrophy and Loss
  • 7. Relationship between Extent of Pathological Changes and Degree of Dementia
  • 8. Pathogenetic Considerations
  • 9. Concluding Remarks
  • 10. References
  • 2 Basal Forebrain Cholinergic Neurons and Alzheimer’s Disease
  • 1. Introduction
  • 2. Basal Forebrain Cholinergic Systems
  • 3. Cholinergic Alterations in AD
  • 4. Cholinergic Physiology
  • 5. Conclusion
  • 6. References
  • 3 Neurochemical Studies in Dementia
  • 1. Introduction
  • 2. Alzheimer’s Disease
  • 3. Other Cortical Dementias
  • 4. Subcortical Dementias
  • 5. Alcohol Dementia
  • 6. Confusional States
  • 7. Summary
  • 8. References
  • 7 The Cholinergic Hypothesis of Memory: A Review of Animal Experiments
  • 1. Introduction
  • 2. Conceptual Issues
  • 3. Methodological Issues
  • 4. Anatomy of Forebrain Cholinergic Pathways
  • 5. Pharmacology of Central Cholinergic Neurons
  • 6. Pharmacological Evidence for Cholinergic Involvement in Sensory, Attentional, and Motor Functions
  • 7. Pharmacological Studies of Rodent Learning and Memory
  • 8. Lesion Studies
  • 9. Pharmacological Studies of Primate Memory
  • 10. Summary and Concluding Remarks
  • 11. References
  • 8 Behavioral Models of Aging in Nonhuman Primates
  • 1. Introduction
  • 2. Some Characteristics of Age-Related Behavioral Deficits in Nonhuman Primates
  • 3. Relationship of Age-Related Behavioral Deficits in Nonhuman Primates to Humans
  • 4. Relationship of Age-Related Behavioral Deficits in Nonhuman Primates to Rodents
  • 5. Possible Insights from Comparisons with Nonhuman Primates Given Discrete Brain Lesions
  • 4. Distribution of Drugs in Brain
  • 5. Neuropsychopharmacological Studies
  • 6. Neurochemical Studies
  • 7. Relationship to Endogenous Substances
  • 8. Nootropic Drugs and Arguments for Supplementary Choline
  • 9. Clues to the Mode of Action of Nootropic Drugs
  • 10. Some Thoughts on Clinical Trials
  • 11. Summary and Conclusion
  • 12. References
  • 6. Possible Insights from Drugs That Impair Performance on Memory Tasks in Young Subjects
  • 7. Drugs for Improving Age-Related Cognitive Losses: Current Status and Future Prospects
  • 8. Synthesis and Discussion
  • 9. References
  • 9 Cholinergic Drugs and Human Cognitive Performance
  • 1. Introduction
  • 2. The Effects of Cholinergic Agents on Processes Involved in Learning and Memory in Experimental Animals
  • 3. The Effects of Cholinergic Agents on Processes Involved in Learning and Memory in Young Adult Human Subjects
  • 4. Clinical Trials of Cholinergic Agents in Patients with Dementia of the Alzheimer Type or Aged Volunteers
  • 5. Implications and New Directions
  • 6. References
  • 10 Treatment ofDementia with Vasoactive Drugs
  • 1. Background and Rationale
  • 2. Traditional Vasodilators
  • 3. Recent Developments and Future Prospects
  • 4. References
  • 11 New Pharmacological Perspectives on Nootropic Drugs
  • 1. Introduction
  • 2. Known Compounds
  • 3. Goals of This Chapter

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