Ir Genes Past, Present, and Future

The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has...

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Bibliographic Details
Main Authors: Pierce, Carl W., Cullen, Susan E. (Author), Kapp, Judith A. (Author), Schwartz, Benjamin D. (Author)
Format: eBook
Language:English
Published: Totowa, NJ Humana 1983, 1983
Edition:1st ed. 1983
Series:Experimental Biology and Medicine
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
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245 0 0 |a Ir Genes  |h Elektronische Ressource  |b Past, Present, and Future  |c by Carl W. Pierce, Susan E. Cullen, Judith A. Kapp, Benjamin D. Schwartz, Donald C. Shreffler 
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505 0 |a Genetic Organization of I-Region Genes -- Chemistry of I-Region Gene Products and DNA Cloning of I-Region Gene Products -- Ir Gene Function: Cellular Site(s) and Mechanism(s) of Action -- The Role of Ia Antigens in Restricted Cell Interactions -- Lessons on Ir Genes Derived from T Cell Clones and T Cell Hybridomas -- Where From Here? 
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700 1 |a Kapp, Judith A.  |e [author] 
700 1 |a Schwartz, Benjamin D.  |e [author] 
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520 |a The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man­ uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad­ dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob­ servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog­ ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev­ eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes