Biological Methylation and Drug Design Experimental and Clinical Role of S-Adenosylmethionine
This book has been developed from its earlier and far less formal presentment as the proceedings of a symposium entitled The Biochemistry of S-Adenosylmethionine as a Basis for Drug Design that was held at the Solstrand Fjord Hotel in Bergen, Norway on June 30-July 4, 1985. The purpose of the sympos...
| Main Authors: | , , |
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| Format: | eBook |
| Language: | English |
| Published: |
Totowa, NJ
Humana
1986, 1986
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| Edition: | 1st ed. 1986 |
| Series: | Experimental Biology and Medicine
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| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- Carcinogenesis and DNA Hypomethylation in Methyl-Deficient Animals
- The Role of Coenzymes and tRNA Modifications in Metabolic Control of Gene Expression
- Relationship Between Methylation and Maturation of Ribosomal RNA in Prokaryotic and Eukaiyotic Cells
- Distribution of m6A in RNA and Its Possible Biological Role
- C. Regulation of S-Adenosylmethionine, S-Adenosylhomocysteine, and Methylthioadenosine Metabolism
- Regulation of S-Adenosylmethionine Synthesis in Human Lymphocytes
- Cancer, Methionine, and Transmethylation
- The Centrality of S-Adenosylhomocysteinase in the Regulation of the Biological Utilization of S-Adenosyhnethionine
- S-Adenosylhomocysteine Hydrolase
- Probes for Examining the Structure and Function of Human S-Adenosylhomocysteine Hydrolase, and for Isolation of cDNA
- Disposition of Endogenous S-Adenosylhomocysteine and Homocysteine Following Exposure to Nucleoside Analogs and Methotrexate
- Methionine Analog Inhibitors of S-Adenosylmethionine Biosynthesis as Potential Antitumor Agents
- Metabolism and Mechanism of Action of Neplanocin A—A Potent Inhibitor of S-Adenosylhomocysteine Hydrolase
- Biological Consequences of S-Adenosyl-L-homocysteinase Inhibition by Acyclic Adenosine Analogs
- Nucleoside Analogs as Antiviral Agents
- Studies Concerning the Mechanism of Action of 3-Deazaadenosine in Leukocytes
- Mechanism-Based Inhibitors of Alkyltransferase
- Sinefungin and Derivatives: Synthesis, Biosynthesis, and Molecular Target Studies in Leishmania
- Regulation of S-Adenosylmethionine and Methylthioadenosine Metabolism in Methylthioadenosine Phosphorylase-Deficient Malignant Cells
- Purification and Properties of Mammalian S’-Methylthioadenosine Phosphorylase and Bacterial 5’-Methylthioadenosine Nucleosidase: Pharmacological Implications and Perspectives
- Uncoupling of Granulopoietic Cell Proliferation and Differentiation by Methylthioadenosine
- D. Clinical Aspects of S-Adenosylmethionine
- AdoMet as a Drug: Pharmacokinetic and Pharmacological Aspects
- A Biochemical Study of Depressed Patients Receiving S-Adenosyl -L-methionine (SAM)
- Noradrenergic and Cardiovascular Effects ofChronic S-Adenosyl-methionine in Healthy Volunteers
- Role of the One-Carbon Cycle in Neuropsychiatry
- Double-Blind Study of S-Adenosylmethionine Versus Placebo in Hip and Knee Arthrosis
- E. Design, Synthesis, and Biological Evaluation of Transmethylation Inhibitors
- Preface
- Tributes
- Acknowledgments
- Contributors
- A. Protein and Phospholipid Methylations
- Protein Methylation at Abnormal Aspartyl Residues
- Enzymology of Protein Methylation: Recent Developments
- Is There a Function for Protein Carboxymethylation in the Nervous System?
- Methyl-Accepting Chemotaxis Proteins in Bacteria
- Biochemistry of Methylated Phospholipids
- Phospholipid Methylation and Cellular Differentiation
- Methylation of Phosphatidylethanolamine: Enzyme Characterization, Regulation, and Physiological function
- Regulation of Phospholipid Methylation by Reversible Phosphorylation
- Brain Phosphatidylcholine Pools as Possible Sources of Free Choline for Acetylcholine Synthesis
- B. Nucleic Acid Methylations
- DNA Methylation: Overview and Prospectives
- Tissue-Specific DNA Methylation Patterns: Biochemistry of Formation and Possible Role
- Regulation of Gene Expression by Site-Specific Promoter Methylation