Triple-Helical Nucleic Acids
The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in...
| Main Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
1996, 1996
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| Edition: | 1st ed. 1996 |
| Subjects: | |
| Online Access: | |
| Collection: | Springer Book Archives -2004 - Collection details see MPG.ReNa |
Table of Contents:
- 1. The Discovery of Triple-Stranded Nucleic Acids
- Basic Physicochemical Properties of Nucleic Acids
- Physicochemical Studies of Model Triple-Stranded Structures
- 2. Methods of Triplex Study
- Physical Methods for Triplex Study
- Immunological Methods
- Affinity Methods
- Electron Microscopy
- X-Ray Analysis
- A Short Overview of Experimental Physical Methods for Triplex Studies
- Theoretical Descriptions of the Triplex Structures
- Enzymatic and Chemical Probing of Triplex Structures
- Enzymatic Methods
- Chemical Methods
- A Short Overview of Chemical and Enzymatic Probes
- Site-Directed Agents
- A Short Overview of Site-Directed Agents
- Conclusion
- 3. General Features of Triplex Structures
- Basic Types of Triplexes
- Molecular Details of Triplex Structure
- DNA—RNA Triplexes
- Kinetics of Triplex Formation
- Thermodynamics of Triplexes
- New Variants of Triplex Structure
- Conclusion
- 4. Triplex Recognition
- Extension of Triplex Recognition Schemes
- Modified Oligomer Backbones
- Protein—DNA Interactions and Triplex Formation
- Triplex DNA—Drug Interactions
- Conclusion
- 5. The Forces Participating in Triplex Stabilization
- Triplex Stabilizing Factors
- Possible Interactions Which Favor and Stabilize Triplexes
- Conclusion
- 6. In Vivo Significance of Triple-Stranded Nucleic Acid Structures
- In Vivo Existence of Triplexes
- Possible Biological Roles of Triplexes
- Other Roles of the PyPu Tracts
- Conclusion
- 7. Possible Spheres of Application of Intermolecular Triplexes
- Applications of Intermolecular Triplex Methodology
- Conclusion
- References