Mutagenesis of the Mouse Genome

The Human Genome Project has changed our approach to biology. Sequence data are being acquired from multiple organisms at a phenomenal pace and mutagenesis is being carried out in many model organisms to discover gene functions. The mouse is the first mammal to be subjected to large-scale mutagenesi...

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Bibliographic Details
Other Authors: Justice, Monica (Editor), Bedell, Mary (Editor)
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 2004, 2004
Edition:1st ed. 2004
Series:Georgia Genetics Review
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • From the Atomic Age to The Genome Project
  • Chemical mutagenesis of the mouse genome: an overview
  • Effects of male germ-cell stage on the frequency, nature, and spectrum of induced specific-locus mutations in the mouse
  • Allelic mutations of the sodium channel SCN8A reveal multiple cellular and physiological functions
  • Towards a mutant map of the mouse – new models of neurological, behavioural, deafness, bone, renal and blood disorders
  • Implementing large-scale ENU mutagenesis screens in North America
  • Genetic mapping and ENU mutagenesis
  • The Mouse Phenome Project
  • Genetically altered mice: phenotypes, no phenotypes, and Faux phenotypes
  • Visualizing the laboratory mouse: capturing phenotype information