Annual Reports in Combinatorial Chemistry and Molecular Diversity

Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and scr...

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Bibliographic Details
Other Authors: Moos, W.H. (Editor), Pavia, M.R. (Editor), Kay, B.K. (Editor), Ellington, Andrew D. (Editor)
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 1997, 1997
Edition:1st ed. 1997
Series:Annual Reports in Combinatorial Chemistry & Molecular Diversity
Subjects:
Online Access:
Collection: Springer Book Archives -2004 - Collection details see MPG.ReNa
Table of Contents:
  • Section I: Combinatorial Chemistry
  • Combinatorial chemistry: A perspective
  • Techniques for mixture synthesis
  • Techniques for single-compound synthesis
  • Recent advances in solid-phase synthesis
  • Selection of supports for solid-phase organic synthesis
  • Solution-phase combinatorial chemistry
  • Analytical methods for the quality control of combinatorial libraries
  • Automated synthesis
  • Applications of combinatorial technology to drug discovery
  • Section II: Combinatorial Biology and Evolution
  • Combinatorial biology and evolution: A perspective
  • Models and search strategies for applied molecular evolution
  • Molecular evolutionary biology
  • Landscapes for molecular evolution: Lessons from in vitro selection experiments with nucleic acids
  • Synthetic peptide libraries
  • Phage display
  • Section III: Informatics and Related Topics
  • Informatics and related topics: A perspective
  • Modern chemical and biological databases
  • Practical high throughput screening
  • Deconvolution methods in solid-phase synthesis
  • Patent strategies in molecular diversity
  • Combinatorial chemistry alliances in the 1990s: Review of deal structures
  • Combinatorial chemistry: The promise fulfilled?
  • A compendium of solid-phase chemistry publications
  • Author Index