Drug Delivery to the Brain Physiological Concepts, Methodologies and Approaches
de Lange (Ph.D.) is Head of the Target SiteEquilibration Group at the Division of Pharmacology of the Leiden Academic Center for Drug Research (LACDR). Her research program focuses on the development of generally applicable predictive PK/PD models on CNS drugs using advanced in vivo animal models a...
| Other Authors: | , , |
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
2014, 2014
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| Edition: | 1st ed. 2014 |
| Series: | AAPS Advances in the Pharmaceutical Sciences Series
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Anatomy and physiology of the blood-brain barriers
- Recent Progress in Blood-Brain Barrier and Blood-CSF Barrier Transport Research: Pharmaceutical Relevance for Drug Delivery to the Brain
- Blood-Brain Barrier (BBB) Pharmacoproteomics: A New Research Field Opened up by Quantitative Targeted Absolute Proteomics (QTAP)
- Drug Metabolism at the Blood-Brain and Blood-CSF Barriers
- Pharmacokinetic Concepts in Brain Drug Delivery
- In vitro models of blood-brain barriers
- In situ and in vivo animal models
- Principles of PET and its Role in Understanding Drug Delivery to the Brain
- PKPD Aspects of Brain Drug Delivery in a Translational Perspective
- Drug Discovery Methods for Studying Brain Drug Delivery and Distribution
- Prediction of Drug Exposure in the Brain from the Chemical Structure
- Integrated Approach to Optimizing CNS Penetration in Drug Discovery: From the old to the new Paradigm and Assessment of Drug-Transporter Interactions
- Pharmacoeconomic Considerations in CNS Drug Development
- Intranasal Drug Delivery to the Brain
- Blood-To-Brain Drug Delivery using Nanocarriers
- Development of new Protein Vectors for the Physiologic Delivery of Large Therapeutic Compounds to the CNS- CNS Gene Therapy Utilizing Intravenously Administered Viral Vectors
- Neurosurgical Approaches: Drug Infusion Directly into the Parenchyma or Cerebrospinal Fluid
- Osmotic Opening of the BBB for Drug Treatment of Brain Tumors (Focus on Methodological Issues)
- Emerging Engineering Technologies for Opening the BBB
- Disease Influence on BBB Transport in Inflammatory Disorders
- Disease Influence on BBB Transport in Neurodegenerative Disorders
- Drug Delivery in the Context of Stroke and Brain Trauma
- Which Drug or Drug Delivery Method can change Clinical Practice for Brain Tumor Therapy?