Gene Function Analysis

The determination of protein function has been a major goal of molecular biology since the founding of the discipline. However, as we learn more about gene function, we discover that the context within which a gene is expressed controls the specific function of that gene. It has become critical to e...

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Bibliographic Details
Other Authors: Ochs, Michael F. (Editor)
Format: eBook
Language:English
Published: Totowa, NJ Humana 2014, 2014
Edition:2nd ed. 2014
Series:Methods in Molecular Biology
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • The Present State and Future Direction of Integrated Gene Function Analysis
  • Performing Integrative Functional Genomics Analysis in GeneWeaver.org
  • Functional Annotation of Differentially Regulated Geneset Using WebGestalt: A Geneset Predictive of Response to Ipilimumab in Tumor Biopsies
  • ­Integrative Data-Mining Tools to Link Fene and Function
  • Detection of Driver Protein Complexes in Breast Cancer Metastasis by Large Scale Transcriptome-Interactome Integration
  • Pattern Identification in Time Course Gene Expression Data with the CoGAPS Matrix Factorization
  • Statistical Tools and R Software for Cancer Driver Probabilities
  • Predicting the Functional Consequences of Somatic Missense Mutations Found in Tumors
  • Determining the Effect of DNA Methylation on Gene Expression in Cancer Cells
  • Reverse Engineering Transcriptional Gene Network
  • Integrating In Silico Resources to Map a Signaling Network
  • A Method for Inducible Gene Over-Expression and Down-Regulation in Emerging Model Species Using Pogostick
  • Construction and Application of Site-specific Artificial Nucleases for Targeted Gene Editing
  • Selection of Recombinant Antibodies from Antibody Gene Libraries
  • Construction of Simple and Efficient siRNA Validation Systems for Screening and Identification of Effective RNAi-Targeted Sequences from Mammalian Genes
  • Rapid Genetic Modification of Mouse Embryonic Stem Cells by Inducible Cassette Exchange Recombination
  • In Ovo Electroporation of miRNA-Based Plasmids to Investigate Gene Functionin the Developing Neural Tube
  • Proteomic Strategies: SILAC and 2D-DIGE - Powerful Tool to Investigate Cellular Alterations
  • Conditional Gene-Trap Mutagenesis in Zebrafish