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MicroRNAs as Tools in Biopharmaceutical Production

MicroRNAs are small, non-coding RNA molecules that interact with target mRNAs to modulate their translation. They are now recognized as widespread and critical regulators of gene expression in the cell. This book is aimed at both industry- and academic-based researchers in the Biopharmaceutical prod...

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Bibliographic Details
Other Authors: Barron, Niall (Editor)
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 2012, 2012
Edition:1st ed. 2012
Subjects:
Pharmaceutical Chemistry
Chemical Bioengineering
Genetics And Genomics
Genetics
Pharmaceutics
Biotechnology
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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520 |a MicroRNAs are small, non-coding RNA molecules that interact with target mRNAs to modulate their translation. They are now recognized as widespread and critical regulators of gene expression in the cell. This book is aimed at both industry- and academic-based researchers in the Biopharmaceutical production space who wish to learn more about these fascinating molecules. It provides an overview of what is currently known about microRNAs including: ·      a description of their biogenesis and mode of action ·      how they can be detected and measured ·      methods for predicting their target genes ·      how we can manipulate their levels in the cell ·      what lessons can be learned from their behaviour in cancer cells Most importantly this volume addresses how microRNAs might be utilised in the bioprocess setting to: ·      gain new understanding of CHO cell biology ·      design microRNAs expression engineering strategies to influence cell characteristics such as proliferation rate or recombinant protein productivity ·      predict phenotypic outcomes in cell line development projects 

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