Epigenetics: Development and Disease
Epigenetics is the phenomenon which fine tunes the processes associated with life, beyond that which is specified by the sequence of the genetic material; DNA. The covalent modification of DNA, DNA associated histones, several non histone proteins as well as non coding RNA coherently operate to esta...
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| Format: | eBook |
| Language: | English |
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Dordrecht
Springer Netherlands
2013, 2013
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| Edition: | 1st ed. 2013 |
| Series: | Subcellular Biochemistry
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- PART I: EPIGENETICS AND EVOLUTION
- 1.1 Chromatin Organization, Epigenetics and Differentiation: An evolutionary perspective
- 1.2 Secondary structures of the core histone N-terminal tails: their role in regulating chromatin structure
- 1.3 Megabase replication domains along the human genome: Relation to chromatin structure and genome organization
- 1.4 Role of DNA methyltransferases in epigenetic regulation in bacteria
- PART II: DEVELOPMENTAL EPIGENETICS
- 2.1 Metabolic aspects of epigenome: Coupling of S-adenosylmethionine synthesis and gene regulation on chromatin by SAMIT module
- 2.2 Epigenetic regulation of male germ cell differentiation
- 2.3 Epigenetic Regulation of Skeletal Muscle Development and Differentiation
- 2.4 Small changes, big effects: chromatin goes aging
- 2.5 Homeotic gene regulation: A paradigm for epigenetic mechanisms underlying organismal development
- PART III: EPIGENETICS AND TRANSCRIPTION REGULATION
- 3.1 Basic mechanisms in RNA Polymerase I transcriptionof the ribosomal RNA genes
- 3.2 The RNA polymerase II transcriptional machinery and its epigenetic context
- 3.3 RNA polymerase III transcriptions - regulated by chromatin structure and regulator of nuclear chromatin organization
- 3.4. The Role of DNA Methylation and Histone Modifications in Transcriptional Regulation in humans
- 3.5 Histone variants and Transcription regulation
- 3.6 Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View
- 3.7 Chromatin structure and organization: the relation with gene expression during development and disease
- PART IV: EPIGENETICS AND DISEASE
- 4.1 Epigenetics and cancer: Development, Differentiation and Pathobiology
- 4.2 Epigenetic Regulation of Cancer Stem Cell Gene Expression
- 4.3 Role of Epigenetic Mechanisms in the Vascular Complications of Diabetes
- 4.4 Epigenetic changes in inflammatory and autoimmune diseases
- 4.5 Epigenetic regulation of HIV-1 persistence and evolving strategies for virus eradication
- 4.6 Epigenetics in Parkinson’s and Alzheimer’s diseases
- 4.7 Cellular Redox, Epigenetics and Diseases
- PART V: UNDERSTANDING OF EPIGENETICS: A CHEMICAL BIOLOGY APPROACH AND EPIGENETIC THERAPY
- 5.1 Stem cell plasticity in development and cancer: Epigenetic origin of cancer stem cells
- 5.2 Histone acetylation as a therapeutic target- Implication of nanodelivery
- 5.3 DNA methylation and Cancer
- 5.4 Role of epigenetics in inflammation-associated diseases
- 5.5 Plasmodium falciparum: Epigenetic control of var gene regulation and disease