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Mast Cells and Tumours from Biology to Clinic

Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increas...

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Bibliographic Details
Main Authors: Ribatti, Domenico, Crivellato, Enrico (Author)
Format: eBook
Language:English
Published: Dordrecht Springer Netherlands 2011, 2011
Edition:1st ed. 2011
Subjects:
Cell Biology
Cytology
Cancer
Cancer Biology
Oncology
Pathology
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Introduction
  • 1. The mast cell
  • 1.1. A historical overview
  • 1.2. Biology of mast cells
  • 2. Mast cell mediators
  • 2.1. Granule composition
  • 2.2. Histamine and serotonin
  • 2.3. Proteases
  • 2.4. Lipid mediators
  • 2.5. Cytokines and growth factors
  • 2.6. Chemokines
  • 3. The tumour cell
  • 3.1. Biology of tumour cell
  • 3.2. The importance of microenvironment in tumor metastasis
  • 3.3. The “seed and soil” theory
  • 4. Tumour angiogenesis
  • 4.1. The angiogenic switch
  • 4.2. Phenotypic and genotypic characteristics of tumor vessels and genetic evidence that tumours are angiogenesis-dependent
  • 4.3.             What is the evidence that genetic instability promotes the angiogenic switch?
  • 4.4. Hypoxic regulation of tumour angiogenesis
  • 4.5.  The role of pericytes in tumour angiogenesis
  • 4.6.   The role of inflammatory cells in tumour angiogenesis
  • 4.7.         Participation of hematopoietic cells and endothelial precursor cells to tumour angiogenesis
  • 4.8.  Alternative mechanisms of tumour angiogenesis
  • 4.9.   Vascular cooption
  • 4.10. The prognostic significance of tumour angiogenesis
  • 4.11. Angiogenesis is not necessarily involved in tumour progression
  • 5. Mast cells and tumours
  • 5.1. Mast cells and tumour growth in humans: pro and contra
  • 6. Mast cells and tumour angiogenesis
  • 6.1.            Mast cell-induced angiogenesis studied by means of in vitro and in vivo assays
  • 6.2. Mast cell-induced angiogenesis studied by means of experimental carcinogenesis
  • 6.3.           Angiogenic factors stored in mast cells
  • 6.4. Mast cells and angiogenesis in human solid tumours
  • 6.5. Mast cells and angiogenesis in human hematological tumours
  • 7. Mast cells and tumour lymphangiogenesis
  • 8. Drug affecting mast cells
  • Concluding remarks and perspectives
  • References.  

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