The Hereditary Basis of Rheumatic Diseases
Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part de...
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| Format: | eBook |
| Language: | English |
| Published: |
Basel
Birkhäuser
2006, 2006
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| Edition: | 1st ed. 2006 |
| Series: | Progress in Inflammation Research
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Genetics of joint inflammation — problems and possibilities
- Genetic studies on rheumatic diseases
- The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes
- Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine
- Gene-based large scale LD-mapping of rheumatoid arthritis-associated genes
- Shared heredity of rheumatic diseases
- Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders
- Shared genes in rheumatic diseases, the role of PD1 and the RUNX genes in disease susceptibility
- The role of B27 and other genes associated with ankylosing spondylitis
- Tools for analysing complexity
- Emerging tools for dissecting complex disease
- Expression analysis of rheumatic diseases, prospects and problems
- The use of humanized MHC mouse strains for studies of rheumatic diseases
- SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells
- A genetic approach to select and validate new targets for treatment of rheumatic diseases