The Hereditary Basis of Rheumatic Diseases

Rheumatoid Arthritis (RA) represents a complex disease where the inheritable component has been estimated to be up to 60%. This PIR volume deals with the genetic basis and regulation of rheumatic diseases. The first part of the book describes genetic studies on rheumatic diseases. The second part de...

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Bibliographic Details
Other Authors: Holmdahl, Rikard (Editor)
Format: eBook
Published: Basel Birkhäuser 2006, 2006
Edition:1st ed. 2006
Series:Progress in Inflammation Research
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Genetics of joint inflammation — problems and possibilities
  • Genetic studies on rheumatic diseases
  • The epidemiology of rheumatoid arthritis and the use of linkage and association studies to identify disease genes
  • Heterogeneity in rheumatoid arthritis based on expression analysis: towards personalised medicine
  • Gene-based large scale LD-mapping of rheumatoid arthritis-associated genes
  • Shared heredity of rheumatic diseases
  • Emerging relationships: rheumatoid arthritis and the PTPN22 associated autoimmune disorders
  • Shared genes in rheumatic diseases, the role of PD1 and the RUNX genes in disease susceptibility
  • The role of B27 and other genes associated with ankylosing spondylitis
  • Tools for analysing complexity
  • Emerging tools for dissecting complex disease
  • Expression analysis of rheumatic diseases, prospects and problems
  • The use of humanized MHC mouse strains for studies of rheumatic diseases
  • SKG mice, a monogenic model of autoimmune arthritis due to altered signal transduction in T-cells
  • A genetic approach to select and validate new targets for treatment of rheumatic diseases