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Numerical Methods for the Life Scientist Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB

Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic r...

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Bibliographic Details
Main Author: Prinz, Heino
Format: eBook
Language:English
Published: Berlin, Heidelberg Springer Berlin Heidelberg 2011, 2011
Edition:1st ed. 2011
Subjects:
Bioinformatics
Computational And Systems Biology
Mathematical And Computational Biology
Biomathematics
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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245 0 0 |a Numerical Methods for the Life Scientist  |h Elektronische Ressource  |b Binding and Enzyme Kinetics Calculated with GNU Octave and MATLAB  |c by Heino Prinz 
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505 0 |a Preparing the computer -- Binding equilibria -- Binding kinetics -- Least squares fit to experimental data -- Multi-parameter fits -- Comparing the two different approaches.   
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653 |a Computational and Systems Biology 
653 |a Mathematical and Computational Biology 
653 |a Biomathematics 
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520 |a Enzyme kinetics, binding kinetics and pharmacological dose-response curves are currently analyzed by a few standard methods. Some of these, like Michaelis-Menten enzyme kinetics, use plausible approximations, others, like Hill equations for dose-response curves, are outdated. Calculating realistic reaction schemes requires numerical mathematical routines which usually are not covered in the curricula of life science. This textbook will give a step-by-step introduction to numerical solutions of non-linear and differential equations. It will be accompanied with a set of programs to calculate any reaction scheme on any personal computer. Typical examples from analytical biochemistry and pharmacology can be used as versatile templates. When a reaction scheme is applied for data fitting, the resulting parameters may not be unique. Correlation of parameters will be discussed and simplification strategies will be offered 

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