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|a 9783642114168
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| 100 |
1 |
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|a Dakubo, Gabriel D.
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| 245 |
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|a Mitochondrial Genetics and Cancer
|h Elektronische Ressource
|c by Gabriel D. Dakubo
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| 250 |
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|a 1st ed. 2010
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| 260 |
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|a Berlin, Heidelberg
|b Springer Berlin Heidelberg
|c 2010, 2010
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| 300 |
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|a XV, 356 p
|b online resource
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| 505 |
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|a The Copy Number Advantage -- Early Cancer Detection and Monitoring Using Changes in the Mitochondrial Genome as Biosensors -- Analysis
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| 653 |
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|a Molecular Medicine
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| 653 |
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|a Molecular biology
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| 653 |
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|a Cancer research
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| 653 |
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|a Human Genetics
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| 653 |
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|a Human genetics
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| 653 |
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|a Cancer Research
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| 041 |
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7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 856 |
4 |
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|u https://doi.org/10.1007/978-3-642-11416-8?nosfx=y
|x Verlag
|3 Volltext
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|a 599.935
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|a 611.01816
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| 520 |
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|a The pivotal role of mitochondrial functions in carcinogenesis is quite well established. However, the critical role of mitochondrial genome alterations to cancer development is muted in traditional textbooks. Recent scientific efforts have provided unequivocal evidence for mitochondrial genome mutations and content changes in cancer development, progression, and therapy. This pioneering book is a unique compilation of mitochondrial genome alterations in cancer. While primarily focused on the emerging role of mitochondrial genome changes, bioenergetics and signaling pathways, attention is also given to the metabolic transformations of the cancer cell, as well as the established altered cell death processes that underlie cancer evolution and treatment resistance
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