Adeno-Associated Virus Methods and Protocols
Today, progress in rAAV-mediated gene transfer is so robust that long-term, efficient, and regulatable transgene expression is reproducibly achieved in large animal models. The complexity of gene transfer agents in the context of their clinical use requires investigators from a wide variety of back...
| Other Authors: | , |
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| Format: | eBook |
| Language: | English |
| Published: |
Totowa, NJ
Humana
2011, 2011
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| Edition: | 1st ed. 2011 |
| Series: | Methods in Molecular Biology
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Adeno-Associated Virus Biology
- Design and Construction of Functional AAV Vectors
- AAV Capsid Structure and Cell Interactions
- Exploiting Natural Diversity of AAV for the Design of Vectors With Novel Properties
- Gene Therapy in Skeletal Muscle Mediated by Adeno-Associated Virus (AAV) Vectors
- AAV-Mediated Liver-Directed Gene Therapy
- Recombinant AAV Delivery to the Central Nervous System
- AAV Mediated Gene Therapy for Retinal Degenerative Diseases
- Adeno-Associated Virus Vector Delivery to the Heart
- Evaluation of the Fate of rAAV Genomes Following in vivo Administration
- Measuring Immune Responses to Recombinant AAV Gene Transfer
- Modification and Labeling of AAV Vector Particles
- AAV-mediated Gene Targeting
- Preclinical Study Design for rAAV
- Biodistribution and Shedding of AAV Vectors
- Production and Purification of Recombinant Adeno-Associated Vectors
- rAAV Vector Product Characterization and Stability Studies
- rAAV Human Trial Experience