CNS Cancer Models, Markers, Prognostic Factors, Targets, and Therapeutic Approaches
Finally, several chapters explore aspects of therapeutic targeting employing small molecules and combinations thereof, various sorts of cells, viruses and immune modulation. In sum, these treatises represent the cutting edge of research that is driven to be of benefit to patients with these dreaded...
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| Format: | eBook |
| Language: | English |
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Totowa, NJ
Humana
2009, 2009
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| Edition: | 1st ed. 2009 |
| Series: | Cancer Drug Discovery and Development
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Neuro-oncogenesis Induced by Nitroso Compounds in Rodents and Strain-Specific Genetic Modifiers of Predisposition
- The Murine GL261 Glioma Experimental Model to Assess Novel Brain Tumor Treatments
- Spontaneous Occurrence of Brain Tumors in Animals: Opportunities as Preclinical Model Systems
- Prognostic Factors and Biomarkers
- p53 Pathway Alterations in Brain Tumors
- The PTEN/PI3 Kinase Pathway in Human Glioma
- Value of 1p/19q and Other LOH Markers for Brain Tumor Diagnosis, Prognosis, and Therapy
- Discovery of Genetic Markers for Brain Tumors by Comparative Genomic Hybridization
- Genomic Identification of Significant Targets in Brain Cancer
- Oncomodulatory Role of the Human Cytomegalovirus in Glioblastoma
- Aberrant EGFR Signaling in Glioma
- Mechanisms of Brain Tumor Angiogenesis
- Vaso-occlusive Mechanisms that IntiateHypoxia and Necrosis in Glioblastoma: The Role of Thrombosis and Tissue Factor
- Stat3 Oncogenic Signaling in Glioblastoma Multiforme
- Inhibition of Ras Signaling for Brain Tumor Therapy
- HGF/c-Met Signaling and Targeted Therapeutics in Brain Tumors
- Combinatorial Therapeutic Strategies for Blocking Kinase Pathways in Brain Tumors
- Targeting of TRAIL Apoptotic Pathways for Glioblastoma Therapies
- The NF-?B Signaling Pathway in GBMs: Implications for Apoptotic and Inflammatory Responses and Exploitation for Therapy
- Targeting Endoplasmic Reticulum Stress for Malignant Glioma Therapy
- Brain Cancer Stem Cells as Targets of Novel Therapies
- The Use of Retinoids as Differentiation Agents Against Medulloblastoma
- Herpes Simplex Virus 1 (HSV-1) for Glioblastoma Multiforme Therapy
- The Development of Targeted Cancer Gene-TherapyAdenoviruses for High-Grade Glioma Treatment
- Harnessing T-Cell Immunity to Target Brain Tumors
- Glioma Invasion: Mechanisms and Therapeutic Challenges
- Animal Models for Central Nervous Tumors
- Modeling Gliomas Using PDGF-Expressing Retroviruses
- Modeling Brain Tumors Using Avian Retroviral Gene Transfer
- Using Neurofibromatosis Type 1 Mouse Models to Understand Human Pediatric Low-Grade Gliomas
- Transgenic Mouse Models of CNS Tumors: Using Genetically Engineered Murine Models to Study the Role of p21-Ras in Glioblastoma Multiforme
- Pten-Deficient Mouse Models for High-Grade Astrocytomas
- The Nf1–/+; Trp53–/+cis Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptibility to Brain Cancer
- Modeling Astrocytomas in a Family of Inducible Genetically Engineered Mice: Implications for Preclinical Cancer Drug Development
- Human Brain Tumor Cell and Tumor Tissue Transplantation Models
- Transformed Human Brain Cells in Culture as a Model for Brain Tumors
- Rat Glioma Models for Preclinical Evaluation of Novel Therapeutic and Diagnostic Modalities
- Transcription Profiling of Brain Tumors: Tumor Biology and Treatment Stratification
- Proteomic Profiling of Human Brain Tumors
- Proteomic Discovery of Biomarkers in the Cerebrospinal Fluid of Brain Tumor Patients
- Epigenetic Profiling of Gliomas
- MicroRNAs in the Central Nervous System and Potential Roles of RNA Interference in Brain Tumors
- Of Escherichia coli and Man: Understanding Glioma Resistance to Temozolomide Therapy
- Brain Tumor Stem Cell Markers
- Therapeutic Targets and Targeting Approaches
- Clinical Agents for the Targeting of Brain Tumor Vasculature
- Bone Marrow-Derived Cells in GBM Neovascularization
- Vascular Targeting of Brain Tumors – Bridging the Gap with Phage Display
- Impact of the Blood–Brain Barrier on Brain Tumor Imaging and Therapy
- Targeting CXCR4 in Brain Tumors
- Molecular Targeting of IL-13R?2 and EphA2 Receptor in GBM
- Molecular Targets for Antibody-Mediated Immunotherapy of Malignant Glioma