Human Gametes and Preimplantation Embryos Assessment and Diagnosis

In recent years, the advancing science and increasing availability of assisted reproduction have given new hope to infertile couples. However, the use of IVF and ART has also led to marked increases in the number of multiple-infant live births. This poses a public health concern, as these neonates h...

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Corporate Author: SpringerLink (Online service)
Other Authors: Gardner, David K. (Editor), Sakkas, Denny (Editor), Seli, Emre (Editor), Wells, Dagan (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 2013, 2013
Edition:1st ed. 2013
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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100 1 |a Gardner, David K.  |e [editor] 
245 0 0 |a Human Gametes and Preimplantation Embryos  |h Elektronische Ressource  |b Assessment and Diagnosis  |c edited by David K. Gardner, Denny Sakkas, Emre Seli, Dagan Wells 
250 |a 1st ed. 2013 
260 |a New York, NY  |b Springer New York  |c 2013, 2013 
300 |a XV, 306 p. 64 illus., 48 illus. in color  |b online resource 
505 0 |a Implications on IVF Outcome -- Analysis of the Zona Pellucida as an Indicator of Oocyte Developmental Potential -- Morphological Assessment of Oocytes, Pronuclear and Cleavage Stage Embryos -- Morphological Assessment of Blastocyst Stage Embryos: Types of Grading Systems and Their Reported Outcomes -- Real Time Imaging Strategies to Improve Morphological Assessment -- Limitations and Benefits of Morphologic Embryo Assessment Strategies: How Far Can Morphological Assessment Go in the Identification of Viable Embryos? -- Sperm Morphologic Characteristics and Their Impact on Embryo Quality and Pregnancy Outcome -- Objective Biomarkers of Sperm Development and Fertility: Assessment of Sperm-Zona Pellucida Binding Ability and Hyaluronic Acid Mediated Selection of Sperm for ICSI Fertilization -- Selecting the Best Sperm and Its Implications in Clinical Practice -- The Origins of Aneuploidy in Human Embryos --  
505 0 |a Carbohydrate Analysis and Embryo Viability -- Identification of Viable Embryos by Non-invasive Measurement of Amino Acids in Culture Media -- Metabolomic Profiling of Embryos Using Spectroscopy -- Microfluidic Devices for the Analysis of Gamete and Embryo Physiology 
505 0 |a Implications for Transcriptomic and Proteomic Embryo Assessment -- Transcriptomics Technology: Promise and Potential Pitfalls -- Transcriptomic Analysis of Cumulus and Granulosa Cells as a Marker of Embryo Viability -- Mass Spectrometry, Proteomics and the Study of Sperm Cell Biology -- Proteomic Analysis of Embryo Viability -- Metabolism of the Viable Human Embryo -- Analysis of Respiration as an Indicator of Oocyte and Embryo Developmental Potential -- Mitochondrial Activity as a Biomarker of Gamete and Embryo Health --  
653 |a Reproductive Medicine 
653 |a Reproductive Medicine 
653 |a Obstetrics/Perinatology/Midwifery 
653 |a Gynecology 
653 |a Obstetrics 
653 |a Gynecology 
700 1 |a Sakkas, Denny  |e [editor] 
700 1 |a Seli, Emre  |e [editor] 
700 1 |a Wells, Dagan  |e [editor] 
710 2 |a SpringerLink (Online service) 
041 0 7 |a eng  |2 ISO 639-2 
989 |b Springer  |a Springer eBooks 2005- 
856 |u https://doi.org/10.1007/978-1-4614-6651-2?nosfx=y  |x Verlag  |3 Volltext 
082 0 |a 612.6 
520 |a In recent years, the advancing science and increasing availability of assisted reproduction have given new hope to infertile couples. However, the use of IVF and ART has also led to marked increases in the number of multiple-infant live births. This poses a public health concern, as these neonates have a higher rate of pre-term delivery, compromising their survival chances and increasing their risk of lifelong disability. By optimizing the selection of gametes and embryos with high probabilities of implantation, it is possible to reduce the number of embryos transferred and, by extension, the number of high-risk multiple gestations, while maintaining or increasing pregnancy rates. Human Gametes and Preimplantation Embryos: Assessment and Diagnosis provides a broad yet concise overview of established and developing methodologies for assessment of gamete and embryo viability in assisted reproduction. This book elucidates the best practices for precisely selecting viable specimens based on morphology and cleavage rate and covers the spectrum of emerging adjunctive technologies for predicting reproductive potential. The authors present their extensive knowledge of “omics” approaches (genomics, transcriptomics, proteomics, and metabolomics), with unbiased delineation of the associated advantages and potential pitfalls. This valuable clinical resource is well suited to infertility specialists, Ob/Gyn physicians, IVF laboratory technicians, and researchers in the fields of embryology and reproductive medicine