Sequential Experimentation in Clinical Trials Design and Analysis
This book presents an integrated methodology for sequential experimentation in clinical trials. The methodology allows sequential learning during the course of a trial to improve the efficiency of the trial design, which often lacks adequate information at the planning stage. Adaptation via sequenti...
| Main Authors: | , , |
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| Format: | eBook |
| Language: | English |
| Published: |
New York, NY
Springer New York
2013, 2013
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| Edition: | 1st ed. 2013 |
| Series: | Springer Series in Statistics
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| Subjects: | |
| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Introduction
- Nonlinear Regression, Experimental Design, and Phase I Clinical Trials
- Sequential Testing Theory and Stochastic Optimization over Time
- Group Sequential Design of Phase II and III Trials
- Sequential Methods for Vaccine Safety Evaluation and Surveillance in Public Health
- Time-Sequential Design of Clinical Trials with Failure-Time Endpoints
- Confidence Intervals and p-Values
- Adaptive Design of Confirmatory Trials
- References