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130626 ||| eng |
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|a 9781461447412
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| 100 |
1 |
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|a Panasci, Lawrence
|e [editor]
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| 245 |
0 |
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|a Advances in DNA Repair in Cancer Therapy
|h Elektronische Ressource
|c edited by Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali
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| 250 |
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|a 1st ed. 2013
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| 260 |
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|a New York, NY
|b Springer New York
|c 2013, 2013
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| 300 |
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|a VIII, 312 p
|b online resource
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| 505 |
0 |
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|a Preface -- Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs -- DNA-PK, a pharmacological target in cancer chemotherapy and radiotherapy? -- Growth factor receptor signaling, DNA damage response, and cancer cell susceptibility to chemotherapy and relapses -- The relationship between DNA-repair genes, cellular radiosensitivity and the response of tumors and normal tissues to radiotherapy -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy -- The role of BRCA1 and BRCA2 in anticancer drug therapy -- DNA-PK in CLL Chemotherapy -- Poly(ADP) ribose polymerase at the interface of DNA damage signalling and DNA repair -- Cellular protection against the antitumor drug bleomycin -- ATR as a Therapeutic Target -- Telomeres, Telomerase and DNA Damage Response in Cancer Therapy -- RAD51 is a key protein of DNA repair and homologous recombination in humans -- Index
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| 653 |
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|a Molecular Medicine
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| 653 |
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|a Molecular biology
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| 653 |
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|a Cancer research
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| 653 |
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|a Cancer Research
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| 700 |
1 |
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|a Aloyz, Raquel
|e [editor]
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| 700 |
1 |
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|a Alaoui-Jamali, Moulay
|e [editor]
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| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
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|b Springer
|a Springer eBooks 2005-
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| 490 |
0 |
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|a Cancer Drug Discovery and Development
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| 856 |
4 |
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|u https://doi.org/10.1007/978-1-4614-4741-2?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 614.5999
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| 520 |
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|a This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined
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