Hedgehog signaling activation in human cancer and its clinical implications
Despite significant progress in our understanding of cancer biology, cancer continues to be the second cause of human mortality. The remarkable responses of cancer patients to inhibitors to the hedgehog signaling pathway implies a promising novel approach to treat cancer. As a result, understanding...
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| Format: | eBook |
| Language: | English |
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New York, NY
Springer New York
2011, 2011
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| Edition: | 1st ed. 2011 |
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| Online Access: | |
| Collection: | Springer eBooks 2005- - Collection details see MPG.ReNa |
Table of Contents:
- Overview of hedgehog signaling pathway
- Regulation of Hh morphogene gradient
- Smoothened Signaling through a G-protein Effector Network.- Kinases and phosphatases in hedgehog signaling
- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer.- Crosstalks between PKC and hedgehog signaling.- Activation of Hh signaling in human cancer.- Hedgehog signaling in pediatric brain tumors
- Hedgehog Signaling in Mammary Gland Development and Breast Cancer
- Hedgehog signaling and cancer therapeutic resistance.- Small-molecule Inhibitors of the Hedgehog Pathway.- Cyclopamine and its derivatives for cancer therapeutics.-