Pharmacological Mechanisms in Alzheimer's Therapeutics

Alzheimer’s is the most common dementia in the elderly. The need for effective therapy of dementia is greater than ever, but there is not, as yet, a drug therapy which can stop or reverse the clinical consequences. There is, however, a great deal of anticipation on the imminent development of effect...

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Bibliographic Details
Other Authors: Cuello, A. Claudio (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 2007, 2007
Edition:1st ed. 2007
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Overview of the Alzheimer's Disease Pathology and Potential Therapeutic Targets
  • Trial Designs and Outcomes to Monitor Novel Therapeutics in Alzheimer's Disease
  • The Pharmacological Treatment of Alzheimer's Disease with Cholinesterase Inhibitors and Memantine
  • M1 Muscarinic Agonists: A Comprehensive Therapy Against Major Hallmarks of Alzheimer's Disease
  • Cholinergic Neurodegeneration in Alzheimer's Disease: Basis for Nerve Growth Factor Therapy
  • The Rationale for Glutamatergic Therapy in Alzheimer's Disease
  • Secretases as Pharmacological Targets in Alzheimer's Disease
  • ?-Secretase as a Target for Alzheimer's Disease
  • The Rationale for an Immunological Approach to Alzheimer's Therapeutics
  • Neuroinflammation, Alzheimer Disease, and Other Aging Disorders
  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs) and Derived A?42-Lowering Molecules for Treatment and Prevention of Alzheimer's Disease (AD)
  • The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics
  • Apolipoprotein E: A Potent Gene-Based Therapeutic Target for the Treatment of Sporadic Alzheimer's Disease
  • Tau Pathology as a Target in Alzheimer's Therapeutics
  • Design of Inhibitors of Amyloid-? Misfolding and Aggregation for Alzheimer's Therapy
  • Potential Applications of Glycosaminoglycan-Related Compounds in Alzheimer's Disease
  • Multifunctional Neuroprotective Drugs for the Treatment of Alzheimer's Disease
  • Interpreting Clinical Studies of Putative Therapeutics for Alzheimer's Disease: The Case of Statins and NSAIDs