Angiogenesis An Integrative Approach from Science to Medicine

Dr. Judah Folkman, “father of angiogenesis”, (1933-2008) was the Director of the Vascular Biology Program, Andrus Professor of Pediatric Surgery, and Professor of Cell Biology at Harvard University's Boston Children's Hospital. In the 1971 issue of The New England Journal of Medicine, he p...

Full description

Bibliographic Details
Other Authors: Figg, William D. (Editor), Folkman, Judah (Editor)
Format: eBook
Language:English
Published: New York, NY Springer US 2008, 2008
Edition:1st ed. 2008
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Regulation of Angiogenesis by von Hippel Lindau Protein and HIF2
  • Nitric Oxide in Tumor Angiogenesis
  • VEGF Signal Tranduction in Angiogenesis
  • Delta-like Ligand 4/Notch Pathway in Tumor Angiogenesis
  • Immune Cells and Inflammatory Mediators as Regulators of Tumor Angiogenesis
  • Contribution of Endothelial Progenitor Cells to the Angiogenic Process
  • Tumor Angiogenesis and the Cancer Stem Cell Model
  • Targeting the Tumor Microenvironment (Stroma) for Treatment of Metastasis
  • Functional Assessments of Angiogenesis
  • Normalization of Tumor Vasculature and Microenvironment
  • Targeted Drug Delivery to the Tumor Neovasculature
  • Models for Angiogenesis
  • Surrogates for Clinical Development
  • Imaging of Angiogenesis
  • Tumor Endothelial Markers
  • Clinical Translation of Angiogenesis Inhibitors
  • Overview and Clinical Applications of VEGF-A
  • Protein Tyrosine Kinase Inhibitors as Antiangiogenic Agents
  • Therapeutic Strategies that Target the HIF System
  • The Clinical Utility of Bevacizumab
  • Development of Thalidomide and Its IMiD Derivatives
  • TNP-470: The Resurrection of the First Synthetic Angiogenesis Inhibitor
  • Clinical Development of VEGF Trap
  • Recent Advances in Angiogenesis Drug Development
  • Combination of Antiangiogenic Therapy with Other Anticancer Therapies
  • Immunotherapy of Angiogenesis with DNA Vaccines
  • Challenges of Antiangiogenic Therapy of Tumors
  • Pharmacogenetics of Antiangiogenic Therapy
  • Angiogenesis in Health & Disease
  • Angiogenesis in the Central Nervous System
  • Lymphatic Vascular System and Lymphangiogenesis
  • Ocular Neovascularization
  • Angiogenesis and Pathology in the Oral Cavity
  • Revascularization of Wounds: The Oxygen-Hypoxia Paradox
  • Journeys in Coronary Angiogenesis
  • Perspectives on the Future of Angiogenesis Research
  • Physiological & Pathological Angiogenesis: Biology of the Angiogenic Process
  • History of Angiogenesis
  • Angiogenesis and Vascular Remodeling in Inflammation and Cancer: Biology and Architecture of the Vasculature
  • Endothelial Cell Activation
  • Pericytes, the Mural Cells of the Microvascular System
  • Matrix Metalloproteinases and Their Endogenous Inhibitors
  • Integrins in Angiogenesis
  • Angiogenesis and Regulatory Proteins
  • Fibroblast Growth Factor-2 in Angiogenesis
  • Vascular Permeability/Vascular Endothelial Growth Factor
  • Platelet-Derived Growth Factor
  • Angiopoietins and Tie Receptors
  • Basement Membrane Derived Inhibitors of Angiogenesis
  • Angiostatin and Endostatin: Angiogenesis Inhibitors in Blood and Stroma
  • Thrombospondins: Endogenous Inhibitors of Angiogenesis
  • Molecular & Cellular Mechanisms of the Angiogenic Process
  • Overview of Angiogenesis During Tumor Growth
  • Hypoxic Regulation of Angiogenesis by HIF-1