Genetically Engineered Mice for Cancer Research : design, analysis, pathways, validation and pre-clinical testing

Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and techn...

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Corporate Author: SpringerLink (Online service)
Other Authors: Green, Jeffrey E. (Editor), Ried, Thomas (Editor)
Format: eBook
Language:English
Published: New York, NY Springer New York 2012, 2012
Edition:1st ed. 2012
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
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100 1 |a Green, Jeffrey E.  |e [editor] 
245 0 0 |a Genetically Engineered Mice for Cancer Research  |h Elektronische Ressource  |b design, analysis, pathways, validation and pre-clinical testing  |c edited by Jeffrey E. Green, Thomas Ried 
250 |a 1st ed. 2012 
260 |a New York, NY  |b Springer New York  |c 2012, 2012 
300 |a XX, 632 p  |b online resource 
505 0 |a Role in Pre-clinical Testing and Personalized Medicine -- Mighty, But How Useful? The Emerging Role of Genetically Engineered Mice in Cancer Drug Discovery and Development -- Index.   
505 0 |a Genomic Pathology -- Genomic DNA Copy Number Alterations in Mouse Cancer Models and Human Cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping (SKY), FISH, and immunocytochemistry -- Expression Profiling of Mouse Models of Human Cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying Mammary Epithelial Stem and Progenitor Cells --  
505 0 |a Insight from Studies in the Engineered Mouse -- Mouse Models for Colorectal Cancer -- Src family tyrosine kinases: Implications for mammary tumor progression -- Maspin and Suppression of Tumor Metastasis -- Epigenetic Mouse Models -- Modeling Transforming Growth Factor-ß Signaling in Cancer -- Modeling Stromal-Epithelial Interactions.-  Utilizing Mouse Models of Human Cancer for Assessing Immune-Modulation of Cancer Development.-  Transplanted Tumor Models For Preclinical Drug Testing And The Potential Benefit Of Genetically Engineered Mouse Models -- The Development and Use of Genetically Tractable Pre-Clinical Mouse Models -- Animal Models for Breast Cancer Prevention Resarch -- Oncogene Addiction: Mouse Models and Clinical Relevance for Molecularly Targeted Therapies -- Mouse Models in Preclinical Drug Development- Applications to CNS Models --  
653 |a Parasitology 
653 |a Cancer research 
653 |a Human Genetics 
653 |a Animal Biochemistry 
653 |a Parasitology 
653 |a Biochemistry 
653 |a Human genetics 
653 |a Cancer Research 
653 |a Medical Microbiology 
653 |a Laboratory Medicine 
653 |a Medical microbiology 
653 |a Laboratory medicine 
700 1 |a Ried, Thomas  |e [editor] 
710 2 |a SpringerLink (Online service) 
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989 |b Springer  |a Springer eBooks 2005- 
856 |u https://doi.org/10.1007/978-0-387-69805-2?nosfx=y  |x Verlag  |3 Volltext 
082 0 |a 614.5999 
520 |a Technological advances in manipulating the mouse genome has led to the development of sophisticated genetically-engineered models of human cancer that recapitulate many molecular, biologic and histologic features of human tumors.  This book provides an overview of the design considerations and technical approaches used to generate these important models of human cancer.   These models are designed to recapitulate molecular aberrations in target organs known to drive human cancers.  State-of-the-art methods to analyze genome and transcriptome alterations in these models and particular relationships to human cancers are presented.  Mouse-human comparisons of tumor pathologies are exemplified.  Criteria for selecting relevant models for preclinical studies that might be translatable to the treatment of human cancers are discussed.  The topics presented in this book will be invaluable to both newcomers to the field as well as established investigators who use genetically-engineered mouse models to study the development, progression and treatment of cancer