Multiple Testing Procedures with Applications to Genomics

Specifically, the book proposes resampling-based single-step and stepwise multiple testing procedures for controlling a broad class of Type I error rates, defined as tail probabilities and expected values for arbitrary functions of the numbers of Type I errors and rejected hypotheses (e.g., false di...

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Bibliographic Details
Main Authors: Dudoit, Sandrine, van der Laan, Mark J. (Author)
Format: eBook
Language:English
Published: New York, NY Springer New York 2008, 2008
Edition:1st ed. 2008
Series:Springer Series in Statistics
Subjects:
Online Access:
Collection: Springer eBooks 2005- - Collection details see MPG.ReNa
Table of Contents:
  • Multiple Hypothesis Testing
  • Test Statistics Null Distribution
  • Overview of Multiple Testing Procedures
  • Single-Step Multiple Testing Procedures for Controlling General Type I Error Rates, ?(Fvn)
  • Step-Down Multiple Testing Procedures for Controlling the Family-Wise Error Rate
  • Augmentation Multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates
  • Resampling-Based Empirical Bayes multiple Testing Procedures for Controlling Generalized Tail Probability Error Rates
  • Simulation Studies: Assessment of Test Statistics Null Distributions
  • Identification of Differentially Expressed and Co-Expressed Genes in High-Throughput Gene Expression Experiments
  • Multiple Tests of Association with Biological Annotation Metadata
  • HIV-1 Sequence Variation and Viral Replication Capacity
  • Genetic Mapping of Complex Human Traits Using Single Nucleotide Polymorphisms: The ObeLinks Project
  • Software Implementation