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090727 ||| eng |
| 020 |
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|a 9781592593484
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| 050 |
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4 |
|a RC434.2-574
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| 100 |
1 |
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|a Leboyer, Marion
|e [editor]
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| 245 |
0 |
0 |
|a Psychiatric Genetics
|h Elektronische Ressource
|b Methods and Reviews
|c edited by Marion Leboyer, Frank Bellivier
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| 250 |
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|a 1st ed. 2003
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| 260 |
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|a Totowa, NJ
|b Humana Press
|c 2003, 2003
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| 300 |
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|a IX, 268 p. 7 illus
|b online resource
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| 505 |
0 |
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|a Psychiatric Genetics -- Methods in Psychiatric Genetics: Advantages and Limits -- Analytical Methods Applied to Psychiatric Genetics -- Genetic Markers in Psychiatric Genetics -- Clinical Assessment in Psychiatric Genetics -- Genetic Association Studies -- New Phenotypic Approaches -- Searching for Alternative Phenotypes in Psychiatric Genetics -- Intermediate Cognitive Phenotypes Associated with Schizophrenia -- Biochemical Endophenotypes in Personality Disorders -- Electrophysiological Phenotypes -- Brain Imaging as an Approach to Phenotype Characterization for Genetic Studies of Schizophrenia -- Conclusion -- Psychiatric Genetics
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| 653 |
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|a Psychiatry
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| 700 |
1 |
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|a Bellivier, Frank
|e [editor]
|
| 041 |
0 |
7 |
|a eng
|2 ISO 639-2
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| 989 |
|
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|b SPRPROT
|a Springer Protocols Archive 1981-2004
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| 490 |
0 |
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|a Methods in Molecular Medicine
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| 024 |
8 |
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|a 10.1385/1592593488
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| 856 |
4 |
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|u https://doi.org/10.1385/1592593488?nosfx=y
|x Verlag
|3 Volltext
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| 082 |
0 |
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|a 616.89
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| 520 |
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|a Enthusiasm about the role that genetics plays in our understanding of behavioral phenotypes has led to the development of many new epidemiological and statistical strategies, as well as to refinements in phenotype analysis. In Psychiatric Genetics: Methods and Reviews, hands-on experts comprehensively review the tools and methods currently available to uncover the genetic basis of psychiatric disorders, and then demonstrate through archetypical examples how these strategies can be used. Casting their net widely, the authors critically examine the key methodological issues involved in phenotypic analysis-including study design, molecular techniques, clinical interviews, and population sampling methods-and discuss new and alternate strategies that identify candidate symptoms and endophenotypes with better genetic validity. These strategies suggest cognitive intermediate phenotypes in schizophrenia, show how personality disorders may generate biologically mediated traits in the full-blown disorders, and yield data about P50 and P300 as endophenotypes in schizophrenia and alcoholism. One of the most promising approaches for the identification of valid phenotypes-the union of neuropsychological experimental designs and in vivo physiological brain mapping-is also discussed. Practical and timely, Psychiatric Genetics: Methods and Reviews lays the cornerstone for the new diagnostics in psychiatric genetics-the unraveling of the genetic basis of psychiatric disorders and the development of new therapies through the precise identification of the phenotypes involved
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