Transgenic Mouse Methods and Protocols
Genetically very similar to the human species, mice play an important role in biomedical research and have served as experimental models for a wide variety of pathologies, including cancer, cardiovascular diseases, and behavioral disorders. In Transgenic Mouse Methods and Protocols, Marten Hofker an...
Other Authors: | , |
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Format: | eBook |
Language: | English |
Published: |
Totowa, NJ
Humana Press
2002, 2002
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Edition: | 1st ed. 2002 |
Series: | Methods in Molecular Biology
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Subjects: | |
Online Access: | |
Collection: | Springer Protocols Archive 1981-2004 - Collection details see MPG.ReNa |
Table of Contents:
- Introduction: The Use of Transgenic Mice in Biomedical Research
- Genetic Modification of the Mouse
- In Vitro Fertilization/Cryopreservation
- Transgene Design
- Generating Conditional Mouse Mutants via Tetracycline-Controlled Gene Expression
- Manipulating Large Insert Clones for Transgenesis
- Reporter Molecules in Genetically Engineered Mice
- Gene Targeting in Mouse Embryonic Stem Cells
- Conditional Knockout Mice
- Knockin Approaches
- Aggregation of Embryos and Embryonic Stem Cells
- Andenovirus-Mediated Gene Transfer
- Random ENU Mutagenesis
- Autopsy and Histologic Analysis of the Transgenic Mouse
- Bone Marrow Transplantations to Study Gene Function in Hematopoietic Cells
- Quantification of Atherosclerosis in Mice
- Genetically Modified Mice in Cancer Research
- Neuropathobiology in Transgenic Mice