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Transgenic Mouse Methods and Protocols

Genetically very similar to the human species, mice play an important role in biomedical research and have served as experimental models for a wide variety of pathologies, including cancer, cardiovascular diseases, and behavioral disorders. In Transgenic Mouse Methods and Protocols, Marten Hofker an...

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Bibliographic Details
Other Authors: Hofker, Marten H. (Editor), van Deursen, Jan (Editor)
Format: eBook
Language:English
Published: Totowa, NJ Humana Press 2002, 2002
Edition:1st ed. 2002
Series:Methods in Molecular Biology
Subjects:
Cell Biology
Cytology
Online Access:
Collection: Springer Protocols Archive 1981-2004 - Collection details see MPG.ReNa
Table of Contents:
  • Introduction: The Use of Transgenic Mice in Biomedical Research
  • Genetic Modification of the Mouse
  • In Vitro Fertilization/Cryopreservation
  • Transgene Design
  • Generating Conditional Mouse Mutants via Tetracycline-Controlled Gene Expression
  • Manipulating Large Insert Clones for Transgenesis
  • Reporter Molecules in Genetically Engineered Mice
  • Gene Targeting in Mouse Embryonic Stem Cells
  • Conditional Knockout Mice
  • Knockin Approaches
  • Aggregation of Embryos and Embryonic Stem Cells
  • Andenovirus-Mediated Gene Transfer
  • Random ENU Mutagenesis
  • Autopsy and Histologic Analysis of the Transgenic Mouse
  • Bone Marrow Transplantations to Study Gene Function in Hematopoietic Cells
  • Quantification of Atherosclerosis in Mice
  • Genetically Modified Mice in Cancer Research
  • Neuropathobiology in Transgenic Mice

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