1 Table of Contents: “...General outline of RNAi technology -- Basic principles and mechanisms of RNAi -- RNAi technological...”

2 Table of Contents: “...Impact of RNAi on biology -- Gene silencing -- Mechanism of unravelling -- Understanding...”

3 Table of Contents: “... -- Successful experimental design -- Appropriate RNAi controls...”

4 Table of Contents: “...RNAi therapeutics development -- RNAi cellular activity -- In vivo siRNA delivery is key...”

5 Table of Contents: “... -- Vectors for delivering genetic material to brain -- AAVs for delivering RNAi for reducing gene expression...”

6 Table of Contents: “...Use of functional cell-based reporter system (Cell Sensor(tm) technology) with RNAi -- From target...”

7 Table of Contents: “...Understanding how RNAi works -- The fruitfly, Drosophila melanogaster model -- The three reasons...”

8 “...RNAi and inflammatory heart diseases...”

9 Table of Contents: “...Small non-coding RNA pathways -- Genetics of RNAi -- MicroRNAs -- RNAi screening -- Biological...”

10 Table of Contents: “...RNAi mechanisms -- RNAi and HIV infection -- Lentiviral vector-mediated transduction of stem cells...”

11 Table of Contents: “... turned over by RNA interference (RNAi) -- RNAi of centromeric transcripts is required for transcriptional...”

12 Table of Contents: “...Functional analysis in Drosophila -- RNAi -- Genetic screens by RNAi -- RNAi libraries -- Cell...”

13 Table of Contents: “...Systemic RNA interference (RNAi): Therapeutics for the treatment of HIV-1 -- HIV life cycle...”

14

15 “...RNAi and neurogenetic diseases...”

16 “...Specific functional roles of RNAi in mammals...”

17 Table of Contents: “...Introduction to selfish genetic elements -- RNAi as a mechanism to defend against selfish gene...”

18 Table of Contents: “...Contents: Introduction to RNA interference (RNAi) -- A history of siRNA -- siRNAs as potential...”

19 Table of Contents: “...Contents: RNAi based screening -- CRISPR based screening -- Genome-wide screening -- Drosophila S2R...”

20 Table of Contents: “... design of RNAi reagents...”