1 “...The time required to translate each study was tracked. The original language versions...”

2 “...The time required to translate each study was tracked. The original language versions...”

3 “... Trials; references of relevant publications, government Web sites. STUDY SELECTION: English-language...”

4

5

6 “... Trials; references of relevant publications, government Web sites. STUDY SELECTION: English-language...”

7 “... in each of the motor and the language domains of the CLN2 Clinical Rating Scale. 2.2. has an aggregate...”

8 “... in each of the motor and the language domains of the CLN2 Clinical Rating Scale. 2.2. has an aggregate...”

9 “... English-language studies using a peer-reviewed search strategy. The following databases were searched...”

10 “... English-language studies using a peer-reviewed search strategy. The following databases were searched...”

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12

13

14

15 “... to identify ongoing trials. We conducted ongoing surveillance through November 22, 2017 to identify any major...”

16 “... to identify ongoing trials. We conducted ongoing surveillance through November 22, 2017 to identify any major...”

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18

19

20 “... malformations was null (pooled RR, 0.44 [95% CI, 0.16 to 1.22], k=5, n=961, I2 0%). Adverse reactions...”