1 Table of Contents: “...Overview of hedgehog signaling pathway -- Regulation of Hh morphogene gradient -- Smoothened...”

2 Table of Contents: “...Structural Biology of Notch Signaling -- Non-Canonical Notch Signaling -- Dual Function of Notch...”

3 Table of Contents: “...Signaling Endosomes -- Nuclear Functions And Trafficking Of Receptor Tyrosine Kinases -- Efficient...”

4 Table of Contents: “...Tyrosine Kinase Signaling Pathways in Normal and Cancer Cells -- Resistance to Tyrosine Kinase...”

5 Table of Contents: “... signaling pathways in multiple myeloma pathogenesis -- mTOR pathway in multiple myeloma -- Jak/STAT...”

6 Table of Contents: “... differentiation and tumor development -- Cadherin-based cell-cell adhesions: adhesion structure, signalling...”

7 Table of Contents: “... -- Role of Triglyceride Lipases in Tumor Metabolism -- mTOR signalling in carcinogenesis -- Nuclear Factor...”

8 “... as well as an introduction for the trainee in the laboratory or clinic. Clinical topics span...”

9 Table of Contents: “... and Genomics -- Transcriptional Regulation in Melanoma -- MiRNAs in Malignant Melanoma -- Altered Signal...”

10 “... will focus on biology of multiple myeloma, especially on oncogenomic changes, cell signaling pathways...”

11 Table of Contents: “... Factor and Tumor-associated macrophages -- TLR Signaling and Tumor-associated Macrophages -- SHIP...”

12 Table of Contents: “... -- FGF-FGFR Signaling in Cancer -- MMPs -- PDGF -- TIE -- VEGF A -- VEGF Ligands -- AXL -- B-Raf -- CKIT...”

13 “... and dissimilarities of changed signaling pathways in the different organ systems and depicts potential therapeutic...”

14 Table of Contents: “.... Leptin in Cancer; Epidemiology and Mechanisms -- 4. Leptin Signaling Pathways as Therapeutic Targets...”

15 Table of Contents: “... of Malawi -- Immunology of HIV-Associated Kaposi Sarcoma -- Targeting Signal Transduction Pathways...”

16 Table of Contents: “... of Cancer -- Immune Co-signaling to Treat Cance -- Managing Regulatory T cells -- Myeloid-Derived Suppressor...”

17 Table of Contents: “... Exosomes as Dendritic Cell Modulators -- Signaling Pathways Mediating Dendritic Cell Dysfunction in Cancer...”

18 Table of Contents: “...Dissecting lnterleukin-6 Classic- and Trans-Signaling in Inflammation and Cancer -- Laser...”

19 Table of Contents: “... Hormone Receptor Signaling by Antiviral Drugs -- 14. Retinoic acid-related orphan receptor (ROR) inverse...”

20 Table of Contents: “... Signaling in Breast Cancer Cells Using Genetically Encoded Biosensors --...”