1 “...Genetic epidemiology I : fundamentals, theory, practice and latest developments...”

2 Table of Contents: “...Stopping a Trial for Futility: The Cooperative New Scandinavian Enalapril Survival Study II...”

3 Table of Contents: “... Studies -- Response-adaptive randomization for clinical trials -- Implementing Adaptive Designs...”

4 Table of Contents: “... Boundaries -- Spending Functions -- Practical Survival Monitoring -- Inference Following a Group-Sequential...”

5 Table of Contents: “... The Randomized Controlled Clinical Trial -- 2 Probability Models and Clinical Medicine -- 3 Significance Tests...”

6 Table of Contents: “... in observational studies -- Part III : step-by-step biostatistics of a clinical trial. Step 1 : investigator...”

7 Table of Contents: “... in Adaptive Designs -- Applications and Case Studies -- Appendix - Software for Adaptive Designs -- Index...”

8 Table of Contents: “...4.2 Study objectives in drug metabolism and pharmacokinetics -- 4.3 Configuration of the database...”

9 Table of Contents: “... Research -- 4. Best Practices and Recommendations for Trial Simulations Within the Context of Designing...”

10 Table of Contents: “... upon the careful design and judicious use of animals in preclinical studies -- This is not only...”

11 Table of Contents: “... of reported findings -- Answering criticisms of randomised controlled trials -- Logical fallacies...”

12 Table of Contents: “... I and II clinical trial duration -- Minimum phase III clinical trial requirements -- Safety studies...”

13 Table of Contents: “... -- Overview of drug development from a non-clinical perspective -- Non-clinical guidance documents and studies...”

14 Table of Contents: “...Overview -- The Evidence Pyramid -- Case Study -- Case-control Study -- Randomized Controlled Trial...”

15 Table of Contents: “... Combination Trial Design -- Conclusion...”

16 Table of Contents: “.... A Runoff-Farming Trial with Almonds in the Negev of Israel -- 4. Results from a Three-Year...”

17 Table of Contents: “... and Motivating Studies -- The History of Surrogate Endpoint Validation -- Validation Using Single-trial Data...”

18 Table of Contents: “... Epidemiologic Study Designs -- Intervention Trials -- Confounding and Interaction -- Epidemiological Field Work...”

19 Table of Contents: “... -- Performing Meta-Analyses with Very Few Studies -- Systematic vs Rapid vs Scoping Reviews -- Living Systematic...”

20 Table of Contents: “...Part two. Replication in biology : overviews and case studies. The value of natural history...”