1 Subjects: “...surveillance bias...”

2 “...Technology assessment report...”

3 “...Technology assessment report...”

4 “...Final research report...”

5 “...Final research report...”

6 “...Final research report...”

7 “... and the number of studies reporting STI outcomes. There was limited evidence suggesting potentially stronger...”

8 “... and the number of studies reporting STI outcomes. There was limited evidence suggesting potentially stronger...”

9

10

11 “..., and Australia. The risk of bias for all reported outcomes was medium for 15 trials and low for 1 trial...”

12 “..., and Australia. The risk of bias for all reported outcomes was medium for 15 trials and low for 1 trial...”

13 “... primarily pre/post studies whose inherent high risk of bias precludes drawing inferences of causality...”

14 “... primarily pre/post studies whose inherent high risk of bias precludes drawing inferences of causality...”

15 “...One RCT of guanfacine extended release also reported significant reductions over placebo in ODD...”

16 “...One RCT of guanfacine extended release also reported significant reductions over placebo in ODD...”

17 “... data from, and rated risk of bias of relevant studies. We conducted meta-analyses or network meta...”

18 “... data from, and rated risk of bias of relevant studies. We conducted meta-analyses or network meta...”