1 “... statistical methods, fidelity to the protocol, patient/provider blinding, and attrition bias. Studies differed...”

2

3 “... complex, systems-focused, and underreported. To achieve this goal, we explored the differences between...”

4 “... complex, systems-focused, and underreported. To achieve this goal, we explored the differences between...”

5

6

7

8

9

10

11

12

13

14 “... response (7 RCTs [n = 1,525]; risk difference [RD], 72/1,000 [95% confidence interval (CI), 2 to 24], I2...”

15 “... response (7 RCTs [n = 1,525]; risk difference [RD], 72/1,000 [95% confidence interval (CI), 2 to 24], I2...”

16

17 “... probably improves depressive symptoms at 30 days (least square mean difference in the Hamilton Rating Scale...”

18 “... for different types of observational study designs does not yet exist...”

19 “... for different types of observational study designs does not yet exist...”

20