1 Subjects: “...Evidence-Based Medicine...”

2 Subjects: “...Evidence-Based Medicine...”

3 Subjects: “...Evidence-Based Medicine...”

4 Subjects: “...Evidence-Based Medicine...”

5 Subjects: “...Evidence-Based Medicine...”

6 Subjects: “...Evidence-Based Medicine...”

7 Subjects: “...Evidence-Based Medicine...”

8 “...Methods future research needs report...”

9 “...Methods future research needs report...”

10 “..., and neonatal death. Additional, longer term outcomes for infants were rare, but when reported included...”

11 “..., and neonatal death. Additional, longer term outcomes for infants were rare, but when reported included...”

12

13 “... reports; and studies lacking relevance to PKU treatment or Phe levels and measures of cognition...”

14

15

16 “...OBJECTIVES: The Vanderbilt Evidence-based Practice Center systematically reviewed evidence...”

17 “...OBJECTIVES: The Vanderbilt Evidence-based Practice Center systematically reviewed evidence...”

18 “... with significant limitations reported improvements in other feeding outcomes with frenotomy, and four poor-quality...”

19 “... with significant limitations reported improvements in other feeding outcomes with frenotomy, and four poor-quality...”

20 “... differing protocols reported conflicting results. Fourteen studies addressed other interventions, most...”