1 “...Because of the nature of the available evidence, we chose to perform a qualitative synthesis rather...”

2 “...Because of the nature of the available evidence, we chose to perform a qualitative synthesis rather...”

3 “...: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness...”

4 “...: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness...”

5 “... including its natural history, biologic mechanisms of disease, and ways to measure elevated Phe to better...”

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