1

2

3 “...]) but not all-cause mortality (calculated IRR, 1.01 [95% CI, 0.92 to 1.11]) with four rounds of LDCT screening...”

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5

6

7

8

9

10 “... in all-cause mortality, cardiovascular-related mortality, myocardial infarction (MI), heart failure...”

11 “... among persons with AF. Eligible outcomes included diagnostic yield, test accuracy, all-cause mortality...”

12 “... in all-cause mortality, cardiovascular-related mortality, myocardial infarction (MI), heart failure...”

13 “... studies, which cannot determine cause-and-effect relationships...”

14 “... studies, which cannot determine cause-and-effect relationships...”

15

16

17 “... with increased blood pressure (mean increase of 0-3.5 mm Hg); orlistat causes gastrointestinal distress in 15...”

18 “... with increased blood pressure (mean increase of 0-3.5 mm Hg); orlistat causes gastrointestinal distress in 15...”

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20