1 “... statistical methods, fidelity to the protocol, patient/provider blinding, and attrition bias. Studies differed...”

2 “... statistical methods, fidelity to the protocol, patient/provider blinding, and attrition bias. Studies differed...”

3 “... AND CONCLUSIONS: Overall, we found no substantial differences in comparative efficacy and effectiveness of second...”

4 “... important differences in efficacy among oral DMARD comparisons (methotrexate, sulfasalazine, leflunomide...”

5

6 “... important differences in efficacy among oral DMARD comparisons (methotrexate, sulfasalazine, leflunomide...”

7

8 “... AND CONCLUSIONS: Overall, we found no substantial differences in comparative efficacy and effectiveness of second...”

9

10

11

12 “... for the risk of bleeding were wide and differences between groups were not statistically significant...”

13 “... for the risk of bleeding were wide and differences between groups were not statistically significant...”

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15

16

17 “... effects with a binary covariate to assess whether efficacy of SGAs differs between older adults (e55 years...”

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20