1 Subjects: “...Randomized Controlled Trials as Topic...”

2 “.... Evidence was generally consistent in direction of effect but with variable precision across studies...”

3 Subjects: “...Cohort Studies...”

4 Subjects: “...Cohort Studies...”

5 “...'s ability to produce valid results for two data scenarios when varying numbers of studies were available...”

6 “...'s ability to produce valid results for two data scenarios when varying numbers of studies were available...”

7 “... SOE). One head-to-head trial comparing exenatide with liraglutide reported a slightly greater...”

8 “... SOE). One head-to-head trial comparing exenatide with liraglutide reported a slightly greater...”

9 “... trials support greater efficacy with the addition of a LABA to an ICS than with a higher dose ICS (high...”

10 “... trials support greater efficacy with the addition of a LABA to an ICS than with a higher dose ICS (high...”

11

12

13 “...Although the decision changes were observed in both directions for individual patients, studies...”

14 “...Although the decision changes were observed in both directions for individual patients, studies...”

15 “... care practice setting...”

16 “... care practice setting...”

17 “... studies; n=76,856) and was over 80 percent in most studies. The specificity ranged from 26.4 to 99.7...”

18 “...We found no evidence on possible harms of these interventions. New studies that address a...”

19 “...We found no evidence on possible harms of these interventions. New studies that address a...”

20 “...: This body of evidence was limited by imprecise effect estimates largely because studies were not powered...”